Evidence map›Paper›PMID 39657871›Full record

SynthesisOsteoarthritis and cartilage2025

Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: An individual participant data meta-analysis of 18,807 hips from the World COACH consortium.

Noortje S Riedstra, Fleur Boel, Michiel M A van Buuren, Harbeer Ahedi, Vahid Arbabi, Nigel Arden, Sara J Baart, Sita M A Bierma-Zeinstra, Flavia M Cicuttini, Timothy F Cootes and 18 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Osteoarthritis and cartilage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Noortje S RiedstraErasmus Medical Center, the Netherlands. Electronic address: n.s.riedstra@erasmusmc.nl.
Fleur BoelErasmus Medical Center, the Netherlands.
Michiel M A van BuurenErasmus Medical Center, the Netherlands.
Harbeer AhediUniversity of Tasmania, Sydney Orthopaedic Research Institute, Australia.
Vahid ArbabiUniversity Medical Center Utrecht, Orthopaedic-Biomechanics Research Group, the Netherlands.
Nigel ArdenUniversity of Oxford, UK.
Sara J BaartErasmus Medical Center, the Netherlands.
Sita M A Bierma-ZeinstraErasmus Medical Center, the Netherlands.
Flavia M CicuttiniMonash University, Australia.
Timothy F CootesUniversity of Manchester, UK.
Kay M CrossleyLa Trobe University, Australia.
David T FelsonBoston University School of Medicine, USA.
Willem Paul GiellisUniversity Medical Center Utrecht, the Netherlands.
Joshua HeereyLa Trobe University, Australia.
Graeme JonesMenzies Institute for Medical Research, Australia.
Stefan KluzekUniversity of Oxford, UK; University of Nottingham, UK.
Nancy E LaneUniversity of California at Davis, United States.
Claudia LindnerUniversity of Manchester, UK.
John A LynchUniversity of California, United States.
Joyce B J van MeursErasmus Medical Center, the Netherlands.
Andrea MoslerLa Trobe University, Australia.
Amanda E NelsonUniversity of North Carolina at Chapel Hill, United States.
Michael C NevittUniversity of California, United States.
Edwin H OeiErasmus Medical Center, the Netherlands.
Jos RunhaarErasmus Medical Center, the Netherlands.
Jinchi TangErasmus Medical Center, the Netherlands.
Harrie WeinansUniversity Medical Center Utrecht, Delft University of Technology, the Netherlands.
Rintje AgricolaErasmus Medical Center, the Netherlands.

Funding

Project 3: Intraarticular MineralizationU19AG076471 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2023 to 2026
$49.0M
Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
Study of Osteoporotic FracturesR01AG005394 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1986 to 2015
$6.1M
UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Amanda E Nelson · 2019 to 2026
$6.1M
Project 3P60AR049465 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JORDAN, JOANNE M. · 2003 to 2008
$6.0M
NIAMS Multidisciplinary Clinical Research CenterP60AR064166 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHWARTZ, TODD A · 2013 to 2017
$5.8M
STUDY OF OSTEOPOROTIC FRACTURES: VERTEBRAL FRACTURESR01AR035583 · NIAMS · KAISER FOUNDATION RESEARCH INSTITUTE · PI HILLIER, TERESA A · 1986 to 2005
$3.2M
NCCDPHP CDC HHS U01 DP003206NCCDPHP CDC HHS U01 DP006266NIAMS NIH HHS P30 AR072571NIAMS NIH HHS P30 AR072580NIAMS NIH HHS P60 AR030701NIAMS NIH HHS P60 AR049465NIAMS NIH HHS P60 AR064166NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NIA NIH HHS U19 AG076471Wellcome Trust 223267
6 · The paper itself

Abstract

objectiveTo study the association between various radiographic definitions of acetabular dysplasia (AD) and incident radiographic hip osteoarthritis (RHOA), and to analyze in subgroups.

methodsHips free of RHOA at baseline and with follow-up within 4-8 years were drawn from the World COACH consortium. The Wiberg center edge angle (WCEA), acetabular depth width ratio (ADR), and the modified acetabular index (mAI) were calculated. AD was defined as WCEA≤25°, and for secondary analyses as WCEA≤20°, ADR ≤250, mAI ≥ 13°, and a combination. A logistic regression model with generalized mixed effects with 3 levels adjusted for age, biological sex, and body mass index (BMI) was used. Descriptive statistics stratified by age, biological sex and BMI were reported.

resultsA total of 18,807 hips from 9 studies were included. Baseline characteristics: age 61.84 (± 8.32) years, BMI 27.40 (± 4.49) kg/m², 70.1% women. 4766 hips (25.3%) had WCEA≤25°. Within 4-8 years (mean 5.8 ±1.6) follow-up, 378 hips (2.0%) developed incident RHOA. We found an association between AD and RHOA (adjusted OR [aOR] 1.80 95% confidence interval [CI] 1.40-2.34). In secondary analyses, all other definitions of AD were also associated with incident RHOA (aOR ranging from 1.52 95% CI 1.19-1.94 to 1.96 95% CI 1.26-3.02). Descriptive statistics showed that the relative risk (RR) in AD hips to develop RHOA was higher compared to non-AD hips in age group 61-70 (RR 1.70), BMI<25 (RR 1.66), and in female hips (RR 1.73).

conclusionAD was consistently associated with incident RHOA. Explorative analyses show that AD hips in women and age group 61-70 years seem to be more at risk of developing RHOA compared to non-AD hips.

Indexed as

AcetabulumDevelopmental Dysplasia of the HipOsteoarthritis, HipAgedFemaleHumansMaleMiddle AgedRadiographyRisk FactorsDevelopmental dysplasiaEpidemiologyHarmonizedHip imagingRisk factor

Identifiers

PMID39657871
PMCPMC12239852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.