Observational study in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04451980 (The HIV, Adipose Tissue Immunology, and Metabolism Study), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Samuel S BailinDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-4990-1013
Siyuan MaDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Andrew S PerryDepartment of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-3342-6158
James G TerryDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-6659-3441
John Jeffrey CarrDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-4398-8237
Sangeeta NairDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Heidi J SilverDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-2237-4903
Mingjian ShiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-1569-9822
Mona MashayekhiDepartment of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0331-2395
Jonathan A KropskiVeterans Health Administration, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
Jane F FergusonDepartment of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-6896-1025
Celestine N WanjallaDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-9159-5414
Suman R DasDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-2496-9724
Ravi ShahVanderbilt Translational and Clinical Cardiovascular Research Center, Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-4471-7156
John R KoetheDepartment of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-6490-6942
Curtis L GabrielDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-1611-3136
Funding
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
Pathophysiology of Metabolically Detrimental Changes in Adipose Distribution, Adipocyte Function, and Adipose Immune Environment on Antiretroviral TherapyR01DK131529 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHEILA COLLINS, John Koethe · 2022 to 2026
$4.2M
The Role of Adipose-Resident T Cells in HIV-Associated Glucose IntoleranceR01DK112262 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KOETHE, JOHN · 2017 to 2021
$3.8M
Determinants of alpha-aminoadipic acid (2-AAA) and relationship to diabetesR01DK117144 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FERGUSON, JANE F · 2018 to 2022
$2.5M
Anti-cytomegalovirus Immune Responses in Atherosclerotic Cardiovascular Disease in Persons Living with HIVK23HL156759 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WANJALLA, CELESTINE N · 2021 to 2025
$860k
Adipose Tissue T Cell Polarization and Metabolic Health in Persons Living with HIVK23DK135414 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Samuel Stuart Bailin · 2023 to 2026
$743k
The Effect of SGLT2 Inhibition on Adipose Tissue Inflammation and Endothelial FunctionK23HL159351 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Mona Mashayekhi · 2023 to 2026
$742k
The Gut-Liver Axis in HIV-Related Non-Alcoholic Fatty Liver DiseaseK23DK135420 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Curtis Lee Gabriel · 2023 to 2026
backgroundPersons with HIV (PWH) on contemporary antiretroviral therapy (ART) are at elevated risk for developing age-related cardiometabolic diseases. We hypothesized that integrative analysis of cross-tissue, multimodal data from PWH could provide insight into molecular programming that defines cardiometabolic phenotypes in this high-risk group.
methodsWe enrolled 93 PWH without diabetes who were virologically suppressed on contemporary ART and obtained measures of insulin resistance, glucose intolerance, and adiposity. We performed circulating lipidomics, proteomics, and metabolomics, as well as subcutaneous adipose tissue (SAT) bulk transcriptomics, and used multiomics factor analysis (MOFA) to perform integrative analyses of these datasets.
resultsThe median age was 43 years, median body mass index 30.8 kg/m2, 81% were male, and 56% were self-identified non-Hispanic White. We identified a specific MOFA factor associated with visceral adipose tissue volume (ρ = -0.43), homeostasis model assessment 2 insulin resistance score (ρ = -0.52), liver density (ρ = 0.43), and other cardiometabolic risk factors, which explained more variance in the SAT transcriptome and circulating lipidome compared with the circulating proteome and metabolome. Gene set enrichment analysis of this factor showed extracellular matrix and inflammatory pathways that primarily mapped to SAT myeloid cells and adipose progenitor cells using single-cell deconvolution. Lipidomic analysis showed that this factor was significantly enriched for triacylglycerol and diacylglycerol species.
conclusionsOur multiomic analysis demonstrated coordinated, multitissue molecular reprogramming in virologically suppressed PWH with elevated cardiometabolic disease risk. Longitudinal studies of PWH with assessments of adipose tissue and lipid handling are necessary to understand mechanisms of cardiometabolic disease in PWH. Clinical Trials Registration. NCT04451980.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The Primacy of Adipose Tissue Gene Expression and Plasma Lipidome in Cardiometabolic Disease in Persons With HIV. · full record | OpenQuestion