Evidence map›Paper›PMID 39657667›Full record

ArticleCell reports. Medicine2024

Multi-modal analysis reveals tumor and immune features distinguishing EBV-positive and EBV-negative post-transplant lymphoproliferative disorders.

Jiaying Toh, Andrea J Reitsma, Tetsuya Tajima, Sheren F Younes, Chimere Ezeiruaku, Kayla C Jenkins, Josselyn K Peña, Shuchun Zhao, Xi Wang, Esmond Y Z Lee and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Predictive biomarkers and preventive strategies for PTLD: a turning point in viro-immunologic precision medicine?Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Jiaying TohDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA; PhD Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA.
Andrea J ReitsmaDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Tetsuya TajimaDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Sheren F YounesDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Chimere EzeiruakuDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Kayla C JenkinsDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Josselyn K PeñaDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA; PhD Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Shuchun ZhaoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Xi WangDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Esmond Y Z LeePhD Program in Stem Cell and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Marla C GlassDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Laurynas KalesinskasInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA; PhD Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA.
Ananthakrishnan GanesanInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA; Institute for Computational and Mathematical Engineering, School of Engineering, Stanford University, Stanford, CA, USA.
Irene LiangDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Joy A PaiPhD Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
James T HardenDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA; PhD Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Francesco VallaniaInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA.
Edward A VizcarraDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA.
Govind BhagatDepartment of Pathology, Columbia University, New York, NY, USA.
Fiona E CraigLaboratory of Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Steven H SwerdlowDivision of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Julie MorscioDepartment of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium.
Daan DierickxDepartment of Hematology, University Hospitals Leuven, and the Laboratory for Experimental Hematology, Department of Oncology, University of Leuven, Leuven, Belgium.
Thomas TousseynDepartment of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
Ansuman T SatpathyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Sheri M KramsDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA; Stanford Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Yasodha NatkunamDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Purvesh KhatriInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA, USA; Stanford Immunology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: pkhatri@stanford.edu.
Olivia M MartinezDepartment of Surgery, Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, USA; Stanford Immunology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: omm@stanford.edu.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
Adjuvant Comparison and Characterization (HIV)75N93022C00052 · NIAID · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2022 to 2025
$19.2M
New Therapeutics for Post-Transplant Lymphoproliferative DisorderR01AI113130 · NIAID · STANFORD UNIVERSITY · PI MARTINEZ, OLIVIA M · 2016 to 2020
$2.0M
Transforming Growth Factor beta in T-Cell Homeostasis and ToleranceR01AI067903 · NIAID · UNIVERSITY OF CINCINNATI · PI DOETSCHMAN, THOMAS · 2006 to 2010
$1.8M
Ultra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600k
Computer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481k
NIAID NIH HHS 75N93022C00052NIAID NIH HHS R01 AI067903NIAID NIH HHS R01 AI113130NIAID NIH HHS T32 AI007290NIAID NIH HHS U19 AI057229NIH HHS S10 OD021763NIH HHS S10 OD025212
6 · The paper itself

Abstract

The oncogenic Epstein-Barr virus (EBV) can drive tumorigenesis with disrupted host immunity, causing malignancies including post-transplant lymphoproliferative disorders (PTLDs). PTLD can also arise in the absence of EBV, but the biological differences underlying EBV(+) and EBV(-) B cell PTLD and the associated host-EBV-tumor interactions remain poorly understood. Here, we reveal the core differences between EBV(+) and EBV(-) PTLD, characterized by increased expression of genes related to immune processes or DNA interactions, respectively, and the augmented ability of EBV(+) PTLD B cells to modulate the tumor microenvironment through elaboration of monocyte-attracting cytokines/chemokines. We create a reference resource of proteins distinguishing EBV(+) B lymphoma cells from EBV(-) B lymphoma including the immunomodulatory molecules CD300a and CD24, respectively. Moreover, we show that CD300a is essential for maximal survival of EBV(+) PTLD B lymphoma cells. Our comprehensive multi-modal analyses uncover the biological underpinnings of PTLD and offer opportunities for precision therapies.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanLymphoproliferative DisordersB-LymphocytesCD24 AntigenHumansLymphoma, B-CellTumor MicroenvironmentCD24 AntigenB cell lymphomaCD300aEpstein-Barr virusmulti-cohort analysismulti-omicspost-transplant lymphoproliferative disordertumor-immune interactionstumor microenvironment

Identifiers

PMID39657667
PMCPMC11722118

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.