ArticleJournal of breast imaging2025
Axillary Lymph Nodes T2 Signal Intensity Characterization in MRI of Patients With Mucinous Breast Cancer: A Pilot Study.
Article in Journal of breast imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
objectiveTo evaluate the T2 signal intensity (SI) of axillary lymph nodes as a potential functional imaging marker for metastasis in patients with mucinous breast cancer.
methodsA retrospective review of breast MRIs performed from April 2008 to March 2024 was conducted to identify patients with mucinous breast cancer and adenopathy. Two independent, masked readers qualitatively assessed the T2 SI of tumors and lymph nodes. The T2 SI ratio for adenopathy and contralateral normal lymph nodes was quantitatively measured using the ipsilateral pectoralis muscle as a reference. Comparisons between malignant and nonmalignant lymph nodes were made using the chi-square test for qualitative assessments and the Mann-Whitney U test for quantitative assessments.
resultsOf 17 patients (all female; mean age, 48.4 ± 10.7 years; range: 29-80 years), 12 had malignant nodes, while 5 had benign nodes. Qualitative assessment revealed that the primary mucinous breast cancer was T2 hyperintense in most cases (88.2%-94.1%). No significant difference in qualitative T2 hyperintensity was observed between malignant and nonmalignant nodes (P = .51-.84). Quantitative T2 SI ratio parameters, including the ratio of mean and minimal node T2 SI to mean ipsilateral pectoralis muscle T2 SI, were higher in malignant nodes vs benign and contralateral normal nodes (P <.05).
conclusionMetastatic axillary lymph nodes exhibit high T2 SI, which could serve as a functional biomarker beyond traditional morphological assessment. Future studies should prioritize investigating more precise measurements, such as T2 mapping, and confirm these results in larger groups and across mucinous neoplasms in other organs.
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