Evidence map›Paper›PMID 39657000›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Estimating Net Bone Formation Relative to Resorption Using Reference Bone Turnover Markers.

Albert Shieh, Arun S Karlamangla, Fatma Gossiel, Richard Eastell, Sherri-Ann Burnett-Bowie, Gail A Greendale

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07254429 (Copenhagen Menopause Study), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07254429 phase2recruitingnot on this map

Copenhagen Menopause Study (COMPASS): A Randomized Clinical Trial

TypeinterventionalSponsorMartin Blomberg JensenRan2025 to 2028Enrolled192ConditionsMenopausal Osteoporosis, Bone MarkersArmsTriptorelin 11.25 mg, Sodium Chloride 0.9%, Estradiol (E2), Testosterone, Placebo gel
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Bone turnover markers in the management of CKD-associated osteoporosis-a European consensus.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Albert ShiehDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-0695-7976
Arun S KarlamanglaDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.
Fatma GossielDivision of Clinical Medicine, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield S5 7AU, UK.ORCID 0000-0002-1433-2001
Richard EastellDivision of Clinical Medicine, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield S5 7AU, UK.ORCID 0000-0002-0323-3366
Sherri-Ann Burnett-BowieMassachusetts General Hospital Endocrine Unit, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-0064-096X
Gail A GreendaleDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-1054-1081

Funding

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old AgeU19AG063720 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria Mori Brooks · 2020 to 2026
$61.3M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause TransitionR01AR075729 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIEH, ALBERT · 2020 to 2025
$1.9M
NIAMS NIH HHS R01 AR075729NIAMS NIH HHS R01AR075729NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NIA NIH HHS U19 AG063720NIH HHSNINR NIH HHS U01 NR004061Office of Research on Women's Health U01AG012495Office of Research on Women's Health U01AG012505Office of Research on Women's Health U01AG012531Office of Research on Women's Health U01AG012535Office of Research on Women's Health U01AG012539Office of Research on Women's Health U01AG012546Office of Research on Women's Health U01AG012553Office of Research on Women's Health U01AG012554Office of Research on Women's Health U01NR004061Office of Research on Women's Health U19AG063720
6 · The paper itself

Abstract

contextIndividually, bone resorption or formation markers do not reflect bone balance.

objective(1) Combine reference bone resorption [collagen type I C-telopeptide (CTX)] and formation [procollagen type I propeptide (PINP)] markers to estimate balance by creating a bone balance index (BBI); (2) examine associations of BBI, CTX, or PINP with bone mineral density (BMD) change.

designMixed effects linear regression quantified associations of BBI, CTX, or PINP with BMD change rate.

settingCommunity-based cohort (Study of Women's Health Across the Nation).

participants535 women transitioning through menopause.

main outcome measuresAnnualized percent change in lumbar spine (LS) and femoral neck (FN) BMD.

resultsIn mixed effects linear regression, adjusted for age, body mass index, race/ethnicity, menopause transition stage, and study site, more negative BBI (less favorable balance) related to more BMD loss. Each SD decrement in BBI was associated with a 0.26% greater decline in LS BMD annually and 0.42% greater decline in FN BMD annually (each P < .0001). In separate models, accounting for the previous covariates, greater CTX or PINP predicted more bone loss. Per SD increment in log2CTX, annual BMD decline was 0.37% greater (P < .0001) and 0.47% greater (P < .0001) at the LS and FN, respectively. Per SD increment in log2PINP, annual BMD loss was 0.22% (P < .0001, LS) and 0.19% (P = .01, FN) greater.

conclusionWhen combined as a BBI, CTX and PINP estimate bone balance; more negative BBI predicts faster BMD loss. Separately, CTX or PINP reflect overall amount of bone turnover; greater CTX or PINP are related to more bone loss.

Indexed as

Bone RemodelingBone ResorptionCollagen Type IOsteogenesisPeptide FragmentsProcollagenAdultAgedBiomarkersBone DensityCohort StudiesFemaleFemur NeckHumansLumbar VertebraeMiddle AgedBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptidePeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptidebone turnoverbone turnover markerscohortepidemiologylongitudinalmenopause

Identifiers

PMID39657000
PMCPMC12261099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.