ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025
Flow-mediated dilation decreases in women, but not men, following mild acute intermittent hypoxia.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Role for endothelin-1 in cardiometabolic dysfunction with intermittent hypoxia.Function (Oxford, England) · 2026Review
- Sex-related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea.Experimental physiology · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
Acute, intermittent exposure to mild hypoxia increases sympathetic nervous system activity, decreases arterial shear rate, and increases blood pressure (BP) in young men. Given that the BP-raising effects of intermittent hypoxia (IH) are less evident in young women, we sought to examine the influence of sex on macro- and microvascular function following IH. BP, macrovascular function [brachial artery flow-mediated dilation (FMD)], microvascular function [reactive hyperemia area under the curve (RHAUC)], and brachial artery shear rate [shear rate area under the curve (SRAUC)] were measured before and following 30 min of IH in 18 young adults (8 women, 23 ± 5 yr). IH elicited an average nadir blood oxygen saturation ([Formula: see text]) of 92 ± 3% (
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