Evidence map›Paper›PMID 39656891›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Lipiodol Pickering Emulsion Stabilized by Iron-Doped Carbon Nanozymes for Liver Transarterial Chemoembolization.

Xiancheng Xia, Yang Li, Rongkang Huang, Yuanbin Wang, Wenxuan Xiong, Hui Zhou, Min Li, Xidong Lin, Youchen Tang, Bo Zhang

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiancheng XiaDepartment of Interventional Center, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, P. R. China.
Yang LiThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, P. R. China.
Rongkang HuangDepartment of General Surgery (Colorectal Surgery), Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, P. R. China.
Yuanbin WangDepartment of General Surgery (Colorectal Surgery), Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, P. R. China.
Wenxuan XiongDepartment of General Surgery (Colorectal Surgery), Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, P. R. China.
Hui ZhouPCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Min LiDepartment of Gastrointestinal Surgery, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, 523326, P. R. China.
Xidong LinFuture Technology School, Shenzhen Technology University, Shenzhen, 518118, P. R. China.
Youchen TangThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, P. R. China.
Bo ZhangDepartment of Interventional Center, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, P. R. China.ORCID https://orcid.org/0000-0001-9780-9049

Funding

Fundamental Research Funds for the Central Universities, Sun Yat-sen University 23yxqntd002Guangdong Major Project of Basic and Applied Basic Research 2023B0303000025Guangzhou Science and Technology Program 202002030348National Key Research and Development Program of China 2021YFC2101700National Natural Science Foundation of China 22271320
6 · The paper itself

Abstract

Transarterial chemoembolization (TACE) utilizing a water-in-oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin-loaded lipiodol emulsion (denoted as ICN-LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron-doped carbon nanozymes (ICN) to mitigate the issue of lipiodol-water separation. This novel emulsion not only solves the instability of conventional lipiodol emulsions, but also facilitates the sustained release of lobaplatin. More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton-like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. By integrating chemotherapy and chemodynamic therapy, ICN-LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN-LPE shows an appealing clinical application prospect for TACE.

Indexed as

Chemoembolization, TherapeuticEthiodized OilIronLiver NeoplasmsAnimalsAntineoplastic AgentsCarbonCell Line, TumorEmulsionsHumansLiverRabbitsAntineoplastic AgentsCarbonEmulsionsEthiodized OilIronchemodynamic therapychemoembolizationliver cancerPickering emulsion

Identifiers

PMID39656891
PMCPMC11791992

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.