Evidence map›Paper›PMID 39656723›Full record

ArticlePloS one2024

Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol.

Maleea D Holbert, Fiona Wood, Andrew J A Holland, Warwick Teague, Roy M Kimble, Dianne Crellin, Cody C Frear, Kristen Storey, Natalie Phillips, Yvonne Singer and 9 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Maleea D HolbertSchool of Nursing and Midwifery, Griffith University, Nathan Campus, South Brisbane, QLD, Australia.ORCID 0000-0002-9902-5122
Fiona WoodPerth Children's Hospital, Nedlands, WA, Australia.ORCID 0000-0001-5427-6588
Andrew J A HollandThe Burns Unit, The Children's Hospital at Westmead, Westmead, NSW, Australia.ORCID 0000-0003-3745-8704
Warwick TeagueMurdoch Children's Research Institute, Surgical Research, Parkville, VIC, Australia.
Roy M KimbleChildren's Health Queensland Hospital and Health Service, South Brisbane, QLD, Australia.
Dianne CrellinBurns Service, The Royal Children's Hospital Melbourne, Parkville, VIC, Australia.
Cody C FrearChildren's Health Queensland Hospital and Health Service, South Brisbane, QLD, Australia.
Kristen StoreySchool of Nursing and Midwifery, Griffith University, Nathan Campus, South Brisbane, QLD, Australia.
Natalie PhillipsChildren's Health Queensland Hospital and Health Service, South Brisbane, QLD, Australia.
Yvonne SingerSchool of Nursing and Midwifery, Griffith University, Nathan Campus, South Brisbane, QLD, Australia.
Tanesha A DimanopoulosSchool of Nursing and Midwifery, Griffith University, Nathan Campus, South Brisbane, QLD, Australia.
Lisa MartinPerth Children's Hospital, Nedlands, WA, Australia.
Leila CuttleFaculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Dimitrios VagenasFaculty of Health, Research Methods Group, School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia.
Steven M McPhailAustralian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of Technology, Brisbane, Kelvin Grove, Australia.
Pauline CallejaCollege of Healthcare Sciences, James Cook University, Cairns, Australia.
Jed DuffFaculty of Health, Centre for Healthcare Transformation, Queensland University of Technology, Brisbane, Australia.
Alexandra De YoungChildren's Health Queensland Hospital and Health Service, South Brisbane, QLD, Australia.
Bronwyn R GriffinSchool of Nursing and Midwifery, Griffith University, Nathan Campus, South Brisbane, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute application of adjunctive negative pressure wound therapy (NPWT) significantly improves time to re-epithelialization in pediatric burn patients. This adjunctive treatment has not yet been broadly or routinely adopted as a standard primary burns dressing strategy. The Implementation of Negative PRessurE for acute Pediatric burns (INPREP) trial will implement and evaluate the impact of adjunctive NPWT in parallel with co-designed implementation strategies and resources across four major pediatric hospitals.

methodsWe will conduct a multi-center, prospective, stepped-wedge cluster randomized controlled trial to implement adjunctive NPWT for acute pediatric burns. Participants will include pediatric burn patients presenting to one of four Australian tertiary pediatric hospitals for burn treatment. The intervention is adjunctive NPWT in parallel with co-designed and tailored implementation strategies and a suite of NPWT implementation resources, which form the INPREP toolkit. Using a hybrid type III design, this trial aims to evaluate the effectiveness of NPWT implementation in parallel with the INPREP toolkit using (i) implementation outcomes (e.g., adoption, appropriateness, acceptability, feasibility, and sustainability) and (ii) clinical outcomes (e.g., days to re-epithelialization, scar management requirements, skin grafting requirements). The primary outcome of this trial is treatment adoption-the proportion of eligible patients who receive NPWT. DISCUSSION: This manuscript outlines a protocol for a hybrid type III stepped-wedge cluster randomized controlled trial of adjunctive NPWT implementation in acute pediatric burn care. We anticipate that NPWT implementation in parallel with the INPREP toolkit will be generalizable to emergency departments and burn services across Australia, and evidence generated will inform pediatric burn care internationally.

trial registrationAustralian and New Zealand Clinical Trials Registry: ACTRN12622000166774. Registered 1 February 2022.

Indexed as

BurnsMulticenter Studies as TopicNegative-Pressure Wound TherapyRandomized Controlled Trials as TopicAdolescentAustraliaChildChild, PreschoolFemaleHumansMaleProspective StudiesRe-EpithelializationWound Healing

Identifiers

PMID39656723
PMCPMC11630585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.