ArticleJournal of occupational health2024
The relationship between air lead and blood lead in a modern US lead-acid battery facility: a longitudinal study.
Article in Journal of occupational health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo date there has been little observational evidence on the relationship between air lead and blood lead at relatively low workplace air lead concentrations. This study sought to improve upon prior studies methodologically and aimed to examine this relationship in a modern workplace environment.
methodsPersonal measurements of air lead and blood lead concentrations were collected in a modern lead-acid battery manufacturing facility in the United States. A total of 236 workers and their 2221 air-blood lead measurement pairs, collected between 2001 and 2021, were included in the statistical analysis. The association between air lead and blood lead was examined using linear mixed-effects models to account for data correlation. Potential confounders adjusted for included age, sex, job department, time trend, tenure, and seasonality.
resultsThe workers were mostly (83%) male and on average 29.75 years of age at the first included measurement. Their air lead concentrations ranged from 1 to 50 (arithmetic mean 16.85) μg/m3; blood lead concentrations ranged from 2 to 35 (arithmetic mean 15.47) μg/dL. After adjusting for potential confounders, a 1 μg/m3 increment in air lead was associated with a 0.025 (95% CI, 0.005-0.045; marginal, semi-partial ${R}^2$ = 0.002) μg/dL higher blood lead.
conclusionsThe relationship between air lead and blood lead at relatively low workplace air lead concentrations over a long employment period may be very weak, but this needs to be further investigated in future observational studies with quantified lead exposures from noninhalation routes and nonoccupational sources.
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