Evidence map›Paper›PMID 39656516›Full record

ArticleeLife2024

Lipid discovery enabled by sequence statistics and machine learning.

Priya M Christensen, Jonathan Martin, Aparna Uppuluri, Luke R Joyce, Yahan Wei, Ziqiang Guan, Faruck Morcos, Kelli L Palmer

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Priya M Christensen *Department of Biological Sciences, University of Texas at Dallas, Richardson, United States.ORCID https://orcid.org/0000-0003-4790-9839
Jonathan Martin *Department of Biological Sciences, University of Texas at Dallas, Richardson, United States.ORCID https://orcid.org/0000-0003-0946-3864
Aparna UppuluriDepartment of Biological Sciences, University of Texas at Dallas, Richardson, United States.ORCID https://orcid.org/0009-0005-6334-8375
Luke R JoyceDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID https://orcid.org/0000-0002-9346-671X
Yahan WeiSchool of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, United States.
Ziqiang GuanDepartment of Biochemistry, Duke University Medical Center, Durham, United States.ORCID https://orcid.org/0000-0002-8082-3423
Faruck MorcosDepartment of Biological Sciences, University of Texas at Dallas, Richardson, United States.ORCID https://orcid.org/0000-0001-6208-1561
Kelli L PalmerDepartment of Biological Sciences, University of Texas at Dallas, Richardson, United States.ORCID https://orcid.org/0000-0002-7343-9271

Funding

Computational Tools to Characterize the Effects of Protein and RNA Variability in Function and InteractionsR35GM133631 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Alonso Faruck Morcos · 2019 to 2026
$3.0M
Roles of novel cationic lipids in bacterial pathogenesisR01AI178692 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI Kelly S Doran, Ziqiang Guan · 2023 to 2026
$2.6M
Adaptive alterations of lipids in mitis group streptococciR01AI148366 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI GUAN, ZIQIANG, PALMER, KELLI LEA · 2020 to 2024
$2.5M
SURFACTANT DEFICIENCY AND AIR POLLUTION SUSCEPTIBILITYR01HL058275 · NHLBI · UNIVERSITY OF CINCINNATI · PI LEIKAUF, GEORGE DOUGLAS · 1996 to 1998
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American Heart Association 10.58275/AHA.23POST1013835.pc.gr.161273National Science Foundation MCB-1943442NIAID NIH HHS R01 AI148366NIAID NIH HHS R01 AI178692NIGMS NIH HHS R35 GM133631NIH HHS R01AI178692NIH HHS R35GM133631
6 · The paper itself

Abstract

Bacterial membranes are complex and dynamic, arising from an array of evolutionary pressures. One enzyme that alters membrane compositions through covalent lipid modification is MprF. We recently identified that

Indexed as

Machine LearningBacterial ProteinsEnterococcusGlycolipidsLysinePhosphatidylglycerolsStreptococcus agalactiaeSubstrate SpecificityBacterial ProteinsGlycolipidsLysinelysylphosphatidylglycerolPhosphatidylglycerolscomputational biologyEnterococcus faecalisenzyme specificityinfectious diseaselipid membranemicrobiologyMprFrestricted Boltzmann machineStreptococcus agalactiaesystems biology

Identifiers

PMID39656516
PMCPMC11630815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.