Evidence map›Paper›PMID 39656486›Full record

ArticleAging and disease2024

Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis.

Sebastián Martínez-López, María Salud García-Gutiérrez, Francisco Navarrete, Isabel Gómez-Hurtado, Pedro Zapater, Enrique Ángel, Oriol Juanola, Juan L López-Cánovas, Paula Boix, Manel C Hadid and 5 more

Abstract read
In one paragraph

Article in Aging and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sebastián Martínez-LópezGrupo de Inmunobiología Hepática e Intestinal, Dpto. Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Alicante, Spain.
María Salud García-GutiérrezIIS ISABIAL, Hospital General Universitario de Alicante, Alicante, Spain.
Francisco NavarreteIIS ISABIAL, Hospital General Universitario de Alicante, Alicante, Spain.
Isabel Gómez-HurtadoIIS ISABIAL, Hospital General Universitario de Alicante, Alicante, Spain.
Pedro ZapaterGrupo de Inmunobiología Hepática e Intestinal, Dpto. Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Alicante, Spain.
Enrique ÁngelGrupo de Inmunobiología Hepática e Intestinal, Dpto. Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Alicante, Spain.
Oriol JuanolaGrupo de Inmunobiología Hepática e Intestinal, Dpto. Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Alicante, Spain.
Juan L López-CánovasDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.
Paula BoixGrupo de Inmunobiología Hepática e Intestinal, Dpto. Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Alicante, Spain.
Manel C HadidGrupo de Inmunobiología Hepática e Intestinal, Dpto. Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Alicante, Spain.
Amaya Puig-KrögerUnidad de Inmunometabolismo e Inflamación, IIS Gregorio Marañón, Hospital Gral Univ Gregorio Marañón, Madrid, Spain.
Manuel D GaheteDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.
Jorge ManzanaresIIS ISABIAL, Hospital General Universitario de Alicante, Alicante, Spain.
Esther CaparrósGrupo de Inmunobiología Hepática e Intestinal, Dpto. Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Alicante, Spain.
Rubén FrancésGrupo de Inmunobiología Hepática e Intestinal, Dpto. Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Alicante, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cirrhosis incidence is significantly increased with age and frequently complicated with neurocognitive dysfunction. We have evaluated the contribution of aging to neuroinflammation in the liver-brain axis in advanced chronic liver disease. Young (6-week-old) and old (9-month-old) mice were included in a 12-week protocol of CCl

Indexed as

AgingBlood-Brain BarrierCognitive DysfunctionLiver CirrhosisLiver Cirrhosis, ExperimentalT-LymphocytesAmmoniaAnimalsBrainCarbon TetrachlorideLiverMaleMiceMice, Inbred C57BLAmmoniaCarbon Tetrachloride

Identifiers

PMID39656486
PMCPMC12339172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.