Evidence map›Paper›PMID 39656348›Full record

ArticleInternal and emergency medicine2025

COmplexity of CARE and Discharge barriers: the 'modern internal medicine patient'. Results from the CO-CARED Study.

Elisa Ceriani, Olivia Milani, Mattia Donadoni, Alberto Benetti, Sergio Antonio Berra, Ciro Canetta, Fabrizio Colombo, Francesco Dentali, Luigi Magnani, Antonino Mazzone and 8 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Internal and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Elisa Ceriani *Internal Medicine Department, Ospedale Luigi Sacco, ASST Fatebenefratelli-Sacco, Milan, Italy. elisa.ceriani@asst-fbf-sacco.it.ORCID 0000-0003-2711-7148
Olivia Milani *Internal medicine Department, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Mattia DonadoniInternal Medicine Department, Ospedale Luigi Sacco, ASST Fatebenefratelli-Sacco, Milan, Italy.
Alberto BenettiInternal Medicine Department, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Sergio Antonio BerraInternal Medicine Department, Azienda Ospedaliera Salvini, Garbagnate Milanese, Italy.
Ciro CanettaHigh Care Internal Medicine Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Fabrizio ColomboInternal Medicine Department, Ospedale Niguarda, Milan, Italy.
Francesco DentaliInternal Medicine Department, ASST Settelaghi, Varese, Italy.
Luigi MagnaniInternal Medicine Department, ASST Pavia, Voghera, Italy.
Antonino MazzoneInternal Medicine Department, ASST Ovest Milanese, Legnano, Italy.
Nicola MontanoInternal medicine Department, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Maria Lorenza MuiesanInternal Medicine Department, ASST Spedali Civili Brescia, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Gian Marco PoddaInternal Medicine Department, ASST Santi Paolo e Carlo, Milan, Italy.
Patrizia Rovere QueriniInternal Medicine Department, IRCCS Ospedale San Raffaele, Milan, Italy.
Alessandro SquizzatoInternal Medicine, Ospedale Sant'Anna ASST Lariana, University of Insubria, Como, Italy.
Giovanni CasazzaDepartment of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan, Italy.
Chiara CogliatiInternal Medicine Department, Ospedale Luigi Sacco, ASST Fatebenefratelli-Sacco, Milan, Italy.
SIMI-FADOI Lombardy Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ongoing demographic, epidemiological and social changes are dramatically raising the clinical and care complexity of patients admitted to internal medicine (IM) departments. Collecting evidence for a better characterization of patients is crucial to tailor future interventions based on patient's real needs. The aim of this prospective multicenter study was to describe the complexity of care of patients hospitalized in IM by calculating the complexity of care (ICC) score, through the combination of clinical instability (NEWS score) and care dependency scales (mICD). Furthermore, social frailty was assessed according to potential difficulty in discharge planning. 3912 patients were enrolled (median age 78 years); 71% had a Charlson Comorbidity Index ≥ 5. The ICC score was high in 14.7% of patients, while 15% exhibited a NEWS score at least moderate. One in four patients presented moderate to critical social frailty. The length of stay was correlated with social frailty, mICD and ICC scores, but not with NEWS. In-hospital mortality was correlated with the severity of all the considered scores. A relevant proportion of IM patients exhibited a high complexity of care. Our data support a model in which approximately 15% of IM beds are designated for clinically unstable patients managed in intermediate care sub-units. The substantial burden of social frailty highlights the urgency of national plans allowing at the same time to cover the needs of not self-sufficient and socially disadvantaged patients, and to efficiently address the issue of emergency department boarding.

Indexed as

Internal MedicinePatient DischargeAgedAged, 80 and overFemaleHumansLength of StayMaleMiddle AgedProspective StudiesClinical instabilityComplexity of careDischarge barriersNEWS score

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.