Evidence map›Paper›PMID 39656327›Full record

ArticleMetabolic brain disease2024

CD47 signaling induces hepatic cell death and microglia activation during hepatic encephalopathy.

Ashwin Jhawer, Gabriel Frampton, Shadikchhya Maya Bhattarai, Sharon DeMorrow, Matthew McMillin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic brain disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashwin JhawerDepartment of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0009-0006-1827-1310
Gabriel FramptonDepartment of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-8467-5077
Shadikchhya Maya BhattaraiDepartment of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0009-0000-1556-3736
Sharon DeMorrowDepartment of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-0511-9778
Matthew McMillinDepartment of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA. matthew.mcmillin@bcm.edu.ORCID 0000-0002-5980-0921

Funding

Role of cholesterol in the pathogenesis of hepatic encephalopathyR01DK135995 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI Sharon DeMorrow · 2024 to 2026
$2.2M
Molecular mechanisms of drug-induced liver injuryR01DK112803 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI DEMORROW, SHARON · 2018 to 2021
$1.4M
NIDDK NIH HHS R01 DK112803NIDDK NIH HHS R01 DK135995
6 · The paper itself

Abstract

Acute liver failure results from severe hepatic injury and can lead to neurological dysfunction known as hepatic encephalopathy (HE). Thrombospondin-1 can contribute to HE by increasing cerebral edema and microglia activation in the azoxymethane (AOM) mouse model. CD47 is a receptor for TSP1 and can directly modulate inflammation in numerous disease states. However, the role of CD47 in the progression of HE is currently unknown. Therefore, the aim of this study was to assess the role of CD47 in liver and brain pathology in the AOM mouse model of HE. C57Bl/6 or CD47 knockout (CD47

Indexed as

CD47 AntigenHepatic EncephalopathyLiverMice, Inbred C57BLMice, KnockoutMicrogliaSignal TransductionAnimalsAzoxymethaneCell DeathLiver Failure, AcuteMaleMiceAzoxymethaneCD47 AntigenCd47 protein, mouseAcute liver failureCD47Hepatic encephalopathy

Identifiers

PMID39656327
PMCPMC11705860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.