Evidence map›Paper›PMID 39656317›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Variability in resistance training trajectories of breast cancer patients undergoing therapy.

Maximilian Koeppel, Karen Steindorf, Martina E Schmidt, Friederike Rosenberger, Joachim Wiskemann

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01106820 nacompletednot on this map

Progressive Resistance Training vs. Relaxation for Breast Cancer Patients During Chemotherapy: A Randomized Controlled Intervention Trial to Evaluate the Biological Mechanisms and Effects of Resistance Training on Fatigue and Quality of Life

TypeinterventionalSponsorGerman Cancer Research CenterRan2010 to 2014Enrolled101ConditionsBreast Cancer, Cancer-related FatigueArmsSupervised progressive resistance training, Supervised progressive muscle relaxation training (Jacobsen method)
NCT01468766 nacompletednot on this map

Effects of a Supervised Progressive Resistance Training With Breast Cancer Patients During Adjuvant Radiotherapy - A Randomised Controlled Intervention Trial

TypeinterventionalSponsorGerman Cancer Research CenterRan2011 to 2014Enrolled160ConditionsBreast Cancer, Cancer-related FatigueArmsSupervised progressive resistance training, Supervised progressive muscle relaxation training (Jacobson method)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maximilian KoeppelInstitute of Sports and Sport Science, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0683-8915
Karen SteindorfDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and University Medical Center Heidelberg, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5215-5651
Martina E SchmidtDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, a partnership between DKFZ and University Medical Center Heidelberg, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2095-2426
Friederike RosenbergerWorking Group Exercise Oncology, Department of Medical Oncology, National Center for Tumor Diseases Heidelberg (NCT Heidelberg) and Heidelberg University Hospital, a partnership between DKFZ and University Medical Center Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4147-2958
Joachim WiskemannWorking Group Exercise Oncology, Department of Medical Oncology, National Center for Tumor Diseases Heidelberg (NCT Heidelberg) and Heidelberg University Hospital, a partnership between DKFZ and University Medical Center Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. joachim.wiskemann@nct-heidelberg.de.ORCID http://orcid.org/0000-0002-5971-5436

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn resistance training (RT), the change in volume-load from training sessions (TS) to TS is an indicator of training progress. Resulting growth trajectories are likely to differ between individuals. Understanding this variation is important for exercise planning in general, but even more for clinical populations. We investigated this variation in breast cancer patients undergoing treatment.

methodsData of 69 patients from two randomized controlled trails were investigated. They conducted a 12-week RT program. We fitted a quadratic Bayesian regression model to the baseline standardized volume-load over the course of the intervention. We allowed all parameters to vary both between exercises and between individuals.

resultsWe observed a positive linear component of 0.093 (95% uncertainty interval (UI) 0.058 to 0.120) and a negative quadratic component of - 0.002 (95% UI -0.008 to 0.001) for the mean trajectory of the change in volume-load. For the different exercises, we observed a dispersion for both the linear (0.043, 95% UI 0.018 to 0.082) and the quadratic component (0.002, 95% UI < 0.001 to 0.004). Variation between individual appears to be approximately four times larger. We also observed between-exercise variation within individuals. Extrapolation of the regression model indicates training progression stagnates after 20.6 TS (95% UI 14.8 to 44.4).

conclusionThere is substantial variation in RT response between breast cancer patients undergoing tumor therapy and in-between exercises. The non-linear trajectory indicates that training progression will eventually plateau, demanding periodization and timely modification.

trial registrationBEATE Study: NCT01106820, Date: April 20, 2010; BEST Study: NCT01468766, Date: November 9, 2011.

Indexed as

Bayes TheoremBreast NeoplasmsResistance TrainingAdultAgedFemaleHumansMiddle AgedAdjuvant tumor treatmentBayesian statisticsExercise oncologyHierarchical modelResponse variability

Identifiers

PMID39656317
PMCPMC11631991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.