Evidence map›Paper›PMID 39656141›Full record

ArticleThe Journal of comparative neurology2024

Developmental and Adult Striatal Patterning of Nociceptin Ligand Marks Striosomal Population With Direct Dopamine Projections.

Emily Hueske, Carrie Stine, Tomoko Yoshida, Jill R Crittenden, Akshay Gupta, Joseph C Johnson, Ananya S Achanta, Smitha Bhagavatula, Johnny Loftus, Ara Mahar and 5 more

Abstract read
In one paragraph

Article in The Journal of comparative neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Emily HueskeMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0009-0009-6861-5961
Carrie StineCenter for the Neurobiology of Addiction, Pain and Emotion, Departments of Anesthesiology and Pharmacology, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-8171-3464
Tomoko YoshidaMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jill R CrittendenMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Akshay GuptaMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0003-3202-0738
Joseph C JohnsonCenter for the Neurobiology of Addiction, Pain and Emotion, Departments of Anesthesiology and Pharmacology, University of Washington, Seattle, Washington, USA.ORCID 0009-0000-9211-1346
Ananya S AchantaCenter for the Neurobiology of Addiction, Pain and Emotion, Departments of Anesthesiology and Pharmacology, University of Washington, Seattle, Washington, USA.
Smitha BhagavatulaMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Johnny LoftusMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Ara MaharMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-4922-5572
Dan HuMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jesus AzocarMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Ryan J GrayMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Michael R BruchasCenter for the Neurobiology of Addiction, Pain and Emotion, Departments of Anesthesiology and Pharmacology, University of Washington, Seattle, Washington, USA.
Ann M GraybielMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Funding

Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI FRANK, MICHAEL J. · 2020 to 2024
$15.9M
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2019 to 2026
$13.0M
Functional and anatomical characterization of the striosomal systemR01MH060379 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Ann M Graybiel · 2000 to 2026
$8.7M
Dissecting stress modulation of pnVTA nociceptin peptide-mediated approach-avoidance behaviorF31DA059438 · NIDA · UNIVERSITY OF WASHINGTON · PI STINE, CAROLYN ANN · 2023 to 2024
$90k
Hock E. Tan and K. Lisa Yang Center for Autism ResearchMallinckrodt FoundationNIDA NIH HHS F31531DA059438-02NIDA NIH HHS F31 DA059438NIDA NIH HHS P30 DA048736NIMH NIH HHS P50 MH119467NIMH NIH HHS R01 MH060379Saks-Kavanaugh FoundationSimons Foundation
6 · The paper itself

Abstract

Circuit influences on the midbrain dopamine system are crucial to adaptive behavior and cognition. Recent developments in the study of neuropeptide systems have enabled high-resolution investigations of the intersection of neuromodulatory signals with basal ganglia circuitry, identifying the nociceptin/orphanin FQ (N/OFQ) endogenous opioid peptide system as a prospective regulator of striatal dopamine signaling. Using a prepronociceptin-Cre reporter mouse line, we characterized highly selective striosomal patterning of Pnoc mRNA expression in mouse dorsal striatum, reflecting the early developmental expression of Pnoc. In the ventral striatum, Pnoc expression in the nucleus accumbens core was grouped in clusters akin to the distribution found in striosomes. We found that Pnoc

Indexed as

Corpus StriatumNociceptinOpioid PeptidesAnimalsDopamineDopaminergic NeuronsMaleMiceMice, Inbred C57BLMice, TransgenicNeural PathwaysProtein PrecursorsReceptors, Dopamine D1Receptors, OpioidDopamineNociceptinOpioid PeptidesprepronociceptinProtein PrecursorsReceptors, Dopamine D1Receptors, Opioiddendron bouquetdopaminenociceptinopioidorphanin F/Qstriatumstriosome

Identifiers

PMID39656141
PMCPMC11629859

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.