Evidence map›Paper›PMID 39656127›Full record

ArticleRadiology2024

Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.

Saloni Mehta, Hannah Peterson, Jean Ye, Ahmad Ibrahim, Gul Saeed, Sarah Linsky, Iouri Kreinin, Sui Tsang, Uzoji Nwanaji-Enwerem, Anthony Raso and 12 more

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Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Saloni MehtaFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0000-0003-1775-4776
Hannah PetersonFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0009-0007-0372-8557
Jean YeFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0000-0001-7928-324X
Ahmad IbrahimFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Gul SaeedFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0000-0003-0642-1968
Sarah LinskyFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0000-0002-4204-7881
Iouri KreininFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Sui TsangFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Uzoji Nwanaji-EnweremFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Anthony RasoFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Jagriti AroraFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Fuyuze TokogluFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Sarah W YipFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
C Alice HahnFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0009-0002-4225-8539
Cheryl LacadieFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0009-0006-3130-4156
Abigail S GreeneFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0000-0001-6011-7903
Sangchoon JeonFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0000-0003-2855-2053
R Todd ConstableFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Declan T BarryFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Nancy S RedekerFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Henry YaggiFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).
Dustin ScheinostFrom the Department of Radiology & Biomedical Imaging (S.M., J.A., F.T., C.L., R.T.C., D.S.), Department of Internal Medicine (A.I., H.Y.), Department of Urology (S.L.), Department of Pulmonary, Critical Care & Sleep Medicine (I.K.), Department of Psychiatry (S.W.Y., D.T.B.), Child Study Center (S.W.Y., D.T.B., D.S.), Yale Center for Clinical Investigation (C.A.H.), Department of Neurosurgery (R.T.C.), and Department of Statistics & Data Science (D.S.), Yale School of Medicine, 300 Cedar St, New Haven, CT 06519; Department of Health Policy, Vanderbilt University, Nashville, Tenn (H.P.); Interdepartmental Neuroscience Program, Yale University, New Haven, Conn (J.Y., S.W.Y., R.T.C., D.S.); Department of Internal Medicine, Roger Williams Medical Center, Providence, RI (G.S.); Yale School of Nursing, New Haven, Conn (S.L., U.N.E., S.J.); Yale University Program of Aging, Yale University, New Haven Conn (S.T.); Frank H. Netter MD School of Medicine, Quinnipiac University, Hamden, Conn (A.R.); Department of Psychiatry, Brigham and Women's Hospital, Boston, Mass (A.S.G.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (R.T.C., D.S.); Department of Research, APT Foundation, New Haven, Conn (D.T.B.); School of Nursing, University of Connecticut, Mansfield, Conn (N.S.R.); and Clinical Epidemiology Research Center, VA CT Health Care Center, West Haven, Conn (H.Y.).ORCID 0000-0002-6301-1167

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
The Collaboration Linking Opioid Use Disorder and Sleep ("CLOUDS") StudyU01HL150596 · NHLBI · YALE UNIVERSITY · PI BARRY, DECLAN T., REDEKER, NANCY S · 2019 to 2024
$5.1M
An Individualized, Multidimensional Dimensional Approach to PsychopathologyR01MH121095 · NIMH · YALE UNIVERSITY · PI CONSTABLE, R TODD, SCHEINOST, DUSTIN · 2019 to 2023
$4.2M
NCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863NHLBI NIH HHS U01 HL150596NIGMS NIH HHS T32 GM007205NIMH NIH HHS R01 MH121095
6 · The paper itself

Abstract

Background Structural and functional MRI studies have revealed brain alterations associated with opioid use disorder (OUD). However, previous research has been limited by small sample sizes, few female participants, and single-modality analyses. Purpose To identify structural and functional brain alterations in individuals with OUD using whole-brain data-driven methods to analyze T1-weighted MRI and resting-state functional MRI (rsfMRI). Materials and Methods This secondary analysis of the Collaboration Linking Opioid Use Disorder and Sleep study compared participants with OUD (data collection February 2021 to February 2023) receiving methadone treatment with healthy control participants (data collection February 2018 to May 2023). T1-weighted MRI and rsfMRI were analyzed using tensor-based morphometry and intrinsic connectivity distribution, respectively. Primary outcome measures included regional brain volumes and functional connectivity. Voxel-wise linear regression was used to assess group differences, with family-wise error correction. Pearson partial correlations were used to examine structure-function relationships. Results Compared with healthy control participants (

Indexed as

BrainMagnetic Resonance ImagingOpioid-Related DisordersAdultFemaleHumansMaleYoung Adult

Identifiers

PMID39656127
PMCPMC11694074

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