ArticleRadiology2024
Prognostic Value of Coronary CT Angiography-Derived Quantitative Flow Ratio in Suspected Coronary Artery Disease.
Abstract readMulticenter Study
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Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 citing paper in PubMed.
- The Long March to Identify Patients With Coronary Artery Disease by Pretest Probability Model.JACC. Asia · 2025Article
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15 authors.
Zehang LiFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0002-4264-8409
Shengxian TuFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0001-9681-1067
Matthew B MathesonFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0009-0003-0354-1814
Guanyu LiFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0009-0008-4523-8174
Yankai ChenFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).
Carlos E RochitteFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).
Marcus Y ChenFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0003-0743-9369
Marc DeweyFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0002-4402-2733
Julie M MillerFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).
Bruna R Scarpa MatuckFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0002-2838-9201
Wenjie YangFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0002-3959-5043
Le QinFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0002-8244-8217
Fuhua YanFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0002-5910-1506
João A C LimaFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0001-8756-6995
Armin Arbab-ZadehFrom the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).ORCID 0000-0003-2516-9083
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The prognostic value of coronary CT angiography (CTA)-derived quantitative flow ratio (CT-QFR) remains unknown. Purpose To determine the prognostic value of CT-QFR in predicting the long-term outcomes of patients with suspected coronary artery disease (CAD) in comparison with invasive coronary angiography (ICA)/SPECT and to determine the influence of prior percutaneous coronary intervention (PCI) on the prognostic value of CT-QFR. Materials and Methods In this secondary analysis of the prospective international CORE320 study, 379 participants who underwent coronary CTA and SPECT within 60 days before ICA between November 2009 and July 2011 were included for follow-up. The coronary CTA images were analyzed to determine CT-QFR. The primary outcome was major adverse cardiovascular events (MACEs) in the 5-year follow-up. Kaplan-Meier curves, multivariable Cox regression models adjusted for clinical variables, and areas under the receiver operating characteristic curves (AUCs) were used to assess and compare the predictive ability of CT-QFR and ICA/SPECT. Results CT-QFR computation and 5-year follow-up data were available for 310 participants (median age, 62 years), of whom 205 (66%) were male. CT-QFR (hazard ratio, 1.9 [95% CI: 1.0, 3.5];
Indexed as
Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseAgedFemaleHumansMaleMiddle AgedPrognosisProspective StudiesTomography, Emission-Computed, Single-Photon
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