Evidence map›Paper›PMID 39656118›Full record

ReviewRadiology2024

The QIBA Profile for Dynamic Susceptibility Contrast MRI Quantitative Imaging Biomarkers for Assessing Gliomas.

Mark S Shiroishi, Bradley J Erickson, Leland S Hu, Daniel P Barboriak, Lino Becerra, Laura C Bell, Michael A Boss, Jerrold L Boxerman, Steven Cen, Lisa Cimino and 14 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Mark S Shiroishi *From the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-1422-0288
Bradley J Erickson *From the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0001-7926-6095
Leland S HuFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0001-9282-7619
Daniel P BarboriakFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-2536-6266
Lino BecerraFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-5840-1160
Laura C BellFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0001-8164-8324
Michael A BossFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-9492-767X
Jerrold L BoxermanFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-0594-1542
Steven CenFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-7859-8909
Lisa CiminoFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-7812-5466
Zhaoyang FanFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-2693-0260
Kathryn E KeenanFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0001-9070-5255
John E KirschFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-0389-9475
Nima AmeliFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0009-0005-4072-4438
Sina NazemiFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0001-6737-3037
C Chad QuarlesFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-1731-0940
Mark A RosenFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-1581-0220
Luis RodriguezFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0009-0003-3237-5763
Kathleen M SchmaindaFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0001-6402-2602
Gudrun ZahlmannFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0003-4164-4083
Yuxiang ZhouFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-3462-2305
Nancy ObuchowskiFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0003-1891-7477
Ona WuFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).ORCID 0000-0002-5509-9461
RSNA QIBA Dynamic Susceptibility Contrast MRI Biomarker CommitteeFrom the Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, Calif (M.S.S., S.C., Z.F., N.A., S.N.); Department of Radiology, Mayo Clinic, Rochester, Minn (B.J.E.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (L.S.H., Y.Z.); Division of Neuroradiology, Department of Radiology, Duke University School of Medicine, Durham, NC (D.P.B.); Invicro, Needham, Mass (L.B.); Clinical Imaging Group, Genentech, South San Francisco, Calif (L.C.B.); Imaging Core Laboratory, American College of Radiology, Philadelphia, Pa (M.A.B., L.C.); Section of Neuroradiology, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI (J.L.B.); National Institute of Standards and Technology, Boulder, Colo (K.E.K.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129 (J.E.K., L.R., O.W.); Barrows Neurologic Institute, Phoenix, Ariz (C.C.Q.); Cancer Systems Imaging, MD Anderson Cancer Center, Houston, Tex (C.C.Q.); Department of Radiology, Division of Abdominal Imaging, Hospital of the University of Pennsylvania, Philadelphia, Pa (M.A.R.); College of Undergraduate Studies, University of Central Florida, Orlando, Fla (L.R.); Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.); Independent Consultant, Basel, Switzerland (G.Z.); and Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio (N.O.).

Funding

Quantifying Multiscale Competitive Landscapes of Clonal Diversity in GlioblastomaU01CA220378 · NCI · MAYO CLINIC ARIZONA · PI HU, LELAND, SWANSON, KRISTIN R · 2017 to 2021
$4.3M
Langworthy Diversity Supplement: Image-based models of tumor-immune dynamics in glioblastomaU01CA250481 · NCI · MAYO CLINIC ARIZONA · PI CANOLL, PETER, HU, LELAND · 2021 to 2025
$3.8M
Role of decorin and diffusion MRI in anti-VEGF efficacy for recurrent glioblastomaR01CA270027 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIMOTHY CLOUGHESY, Benjamin M. Ellingson · 2022 to 2026
$3.0M
New treatment monitoring biomarkers for brain tumors using multiparametric MRI with machine learningR01CA255123 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI SCHMAINDA, KATHLEEN MARIE · 2021 to 2025
$2.6M
Establishing the clinical utility of a consensus DSC-MRI ProtocolR01CA264992 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jerrold L Boxerman, Leland Hu · 2022 to 2026
$2.4M
Quantitative molecular MR-PET imaging of glycolysis in glioblastomaR01CA279984 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Benjamin M. Ellingson, David A. Nathanson · 2023 to 2026
$2.4M
Multi-site Validation and Application of a Consensus DSC MRI ProtocolR01CA221938 · NCI · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI BOXERMAN, JERROLD L, HU, LELAND · 2018 to 2020
$738k
NCI NIH HHS R01 CA221938NCI NIH HHS R01 CA255123NCI NIH HHS R01 CA264992NCI NIH HHS R01 CA270027NCI NIH HHS R01 CA279984NCI NIH HHS U01 CA220378NCI NIH HHS U01 CA250481NHLBI NIH HHS HHSN268201500021C
6 · The paper itself

Abstract

The dynamic susceptibility contrast (DSC) MRI measures of relative cerebral blood volume (rCBV) play a central role in monitoring therapeutic response and disease progression in patients with gliomas. Previous investigations have demonstrated promise of using rCBV in classifying tumor grade, elucidating tumor viability after therapy, and differentiating pseudoprogression and pseudoresponse. However, the quantification and reproducibility of rCBV measurements across patients, devices, and software remain a critical barrier to routine or clinical trial use of longitudinal DSC MRI in patients with gliomas. To address this limitation, the RSNA DSC MRI Biomarker Committee of the Quantitative Imaging Biomarkers Alliance developed a Profile that defines statistics-based claims for the precision of longitudinal measurements. Although rCBV is the clinical marker of interest, the Profile focused on the reproducibility of the measured quantitative imaging biomarker, which is the area under the contrast agent concentration-time curve (AUC) normalized by the mean value of normal-appearing contralateral white matter tissue (tissue-normalized AUC values). Based on previous reports of within-subject coefficient of variation (wCV) in the tissue-normalized AUC values for enhancing gliomas (wCV = 0.31), an increase of 182% or more with respect to the baseline tissue-normalized AUC value indicates that an increase has occurred with 95% confidence. In contrast, a decrease of 64% or more with respect to baseline suggests that a decrease has occurred with 95% confidence. Similarly, an increase of 399% or more in the tissue-normalized AUC values in normal brain gray matter tissue (wCV = 0.40) suggests that an increase has occurred with 95% confidence, whereas a decrease of 80% or more with respect to baseline suggests that a decrease has occurred with 95% confidence. This article provides the rationale for these claims and the compliance activities needed to achieve these claims. Potential updates to incorporate new data based on advances in technology and clinical care in the Profile are also discussed.

Indexed as

Brain NeoplasmsContrast MediaGliomaMagnetic Resonance ImagingCerebral Blood VolumeHumansImage Interpretation, Computer-AssistedReproducibility of ResultsContrast Media

Identifiers

PMID39656118
PMCPMC11694077

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