ArticleJournal of the American Chemical Society2024
Iterative One-Carbon Homologation of Unmodified Carboxylic Acids.
Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Acridine/Lewis acid photocatalysis enables α-amidyl radical cyclizations.Organic chemistry frontiers : an international journal of organic chemistry · 2026Article
- Article
- Acridinium amidate as a hydrogen-bonding photocatalyst for direct decarboxylative alkylation of native carboxylic acids.Chemical science · 2026Article
- Photoredox-Neutral Platform for Direct Decarboxylative CyclopropanationACS catalysis · 2026Article
- Homologative alkene difunctionalization.Nature chemistry · 2026Article
- Direct synthesis of bicyclo[1.1.1]pentane (BCP) boronates from carboxylic acids.Nature communications · 2026Article
- Harnessing PNature communications · 2026Article
- One-carbon homologation of alkenes.Nature · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The one-carbon homologation of carboxylic acids is a valuable route to construct families of homologues, which play fundamental roles in chemistry and biology. However, known procedures are based on multistep sequences, use harsh conditions or are limited in scope. Thus, almost a century after the discovery of the original Arndt-Eistert homologation sequence, a general method to directly convert carboxylic acids into their corresponding homologues remains elusive. Exploiting the photoredox reactivity of nitroethylene, we disclose a practical visible-light-induced homologation of unmodified carboxylic acids. Iterations of the procedure reveal an exceptionally tunable strategy for the construction of inert carbon spacers, opening new opportunities in synthesis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.