Trial reportInternational endodontic journal2025
A 4-year follow-up of root canal obturation using a calcium silicate-based sealer and a zinc oxide-eugenol sealer: A randomized clinical trial.
Trial report in International endodontic journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of root canal filling techniques and materials on endodontic treatment outcomes: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- A 4-year follow-up of root canal obturation using a calcium silicate-based sealer and a zinc oxide-eugenol sealer: A randomized clinical trial.International endodontic journal · 2025Trial
- Post-Operative Pain After Endodontic Instrumentation, Irrigation and Obturation: An Umbrella Review of Systematic Reviews Published from 2016 to 2025.Journal of clinical medicine · 2026Review
- Immediate and short-term clinical outcomes of iRoot SP in root canal retreatment: a retrospective study.Clinical oral investigations · 2026Article
- Single cone versus carrier-based obturation using a premixed bioceramic sealer in postgraduate master cohort: a 36 months retrospective evaluation.Clinical oral investigations · 2026Article
- Five-year clinical outcomes of root canal treatment using a calcium silicate-based sealer in teeth with apical periodontitis: a retrospective cohort study.Clinical oral investigations · 2026Article
- Single-Cone vs. Carrier-Based Root Canal Obturation with a Calcium-Silicate-Based Sealer: An In Vitro µ-CT Analysis.Biomimetics (Basel, Switzerland) · 2026Article
- Successful Nonsurgical Resolution of a Large Periapical Lesion With Pre-Existing Sealer Extrusion and Adjacent External Inflammatory Root Resorption: A Case Report.Case reports in dentistry · 2026Article
- Adverse tissue reaction to a next-generation bioceramic sealer: a structured literature review and case report.Frontiers in dental medicine · 2026Review
- Periapical Lesion Healing After Retreatment and Root Canal Filling with a Bioceramic-Based Sealer: A Randomized Clinical Study with 1-Year Follow-Up.Journal of clinical medicine · 2025Article
- Clinical and Radiographic Outcomes of Root Canal Obturation with Hydraulic Condensation and Tricalcium Silicate Bioceramic Sealer: A 12-Month Observational Study on Periapical Healing.Journal of functional biomaterials · 2025Article
- A novel root canal filling technique using a resin-based sealer without gutta-percha: a summary of two cases.BMC oral health · 2025Article
- Quality of Single-Cone Obturation Using Different Sizes of Matching Gutta-Percha Points of Two Reciprocating Single-File Systems in Curved and Straight Root Canals.Medicina (Kaunas, Lithuania) · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
aimThis randomized clinical trial assessed the outcomes of nonsurgical root canal treatment (RCT), comparing a calcium silicate-based sealer (CSBS) with the single-cone technique (SC) with a zinc oxide-eugenol (ZOE) sealer and warm vertical compaction (WVC). METHODOLOGY: Ninety-two single- and multi-rooted teeth were divided into two groups and treated using either the SC with BioRoot™ RCS (BIO) or WVC with Pulp Canal Sealer™ EWT (PCS). Teeth with apical periodontitis (AP) in both groups were further divided into BIOAP and PCSAP subgroups. Standardized instrumentation and disinfection protocols were followed. Periapical index (PAI) was recorded, and clinical and radiographic follow-ups were conducted at 1, 3, 6, 12, 24, and 48 months. Outcomes considered included success rate (under strict and loose criteria), extraction, length of filling, voids, and extrusion rate, as well as changes in PAI score from baseline. Outcome variables and prognostic factors were analysed using binary and multiple logistic regression at p < .05.
resultsSixty-seven teeth were included (recall rate, 73%). At 4-year follow-up, the overall success rates (BIO + PCS) were 89.6% by loose criteria and 83.3% by strict criteria. Subgroup success rates (BIOAP+PCSAP) were 88.5% by loose criteria and 80.4% by strict criteria. There were no significant differences between the groups in terms of success rate, extraction rate, length of filling, voids, or extrusion (p > .05). The pattern of PAI reduction was similar in both groups (p = .806).
conclusionTreatment using the SC-CSBS technique and the ZOE sealer with the WVC technique demonstrated a similar success rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.