Evidence map›Paper›PMID 39655539›Full record

ArticleEuropean journal of neurology2025

Sex-related differences in amyotrophic lateral sclerosis: A 2-[

Antonio Canosa, Alessio Martino, Umberto Manera, Alessandro Giuliani, Rosario Vasta, Francesca Palumbo, Maurizio Grassano, Silvia Daniela Morbelli, Matteo Pardini, Agostino Chiaravalloti and 13 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Antonio CanosaALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Alessio MartinoDepartment of Business and Management, LUISS University, Rome, Italy.
Umberto ManeraALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0002-9995-8133
Alessandro GiulianiEnvironment and Health Department, Istituto Superiore di Sanità, Rome, Italy.
Rosario VastaALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Francesca PalumboALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Maurizio GrassanoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Silvia Daniela MorbelliDepartment of Medical Sciences, University of Turin, Turin, Italy.
Matteo PardiniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Agostino ChiaravallotiDepartment of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy.
Orazio SchillaciDepartment of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy.
Klaus Leonard LeendersDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rosalie Vered KoganDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Giulia PolverariPositron Emission Tomography Centre AFFIDEA-IRMET S.p.A, Turin, Italy.
Grazia ZoccoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Francesca Di PedeALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Filippo De MatteiALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Sara CabrasALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Enrico MatteoniALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Cristina MogliaALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0001-7377-7222
Andrea CalvoALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.ORCID 0000-0002-5122-7243
Adriano ChiòALS Centre, 'Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.
Marco PaganiInstitute of Cognitive Sciences and Technologies, C.N.R, Rome, Italy.

Funding

Dipartimenti di EccellenzaFondation Thierry LatranMinistero della Salute RF-2016- 02362405Ministero dell'Università e della Ricerca 2017SNW5MBSeventh Framework Programme 259867
6 · The paper itself

Abstract

purposeWe investigated sex-related brain metabolic differences in Amyotrophic Lateral Sclerosis (ALS) and healthy controls (HC).

methodsWe collected two equal-sized groups of male (m-ALS) and female ALS (f-ALS) patients (n = 130 each), who underwent 2-[

resultsM-ALS showed relative hypometabolism of bilateral medial frontal, parietal and occipital cortices, and left temporal cortex, compared to f-ALS. In node-wise comparison, f-ALS showed significantly higher connectivity in right middle cingulate cortex and left superior and medial frontal gyrus. In HC we did not find any sex-related differences.

conclusionSex resulted a major determinant of brain metabolism and connectivity in ALS patients.

Indexed as

Amyotrophic Lateral SclerosisBrainFluorodeoxyglucose F18Positron-Emission TomographySex CharacteristicsAdultAgedFemaleHumansMaleMiddle AgedFluorodeoxyglucose F182‐[18F]FDG‐PETamyotrophic lateral sclerosisbrain connectivitybrain metabolismsex differences

Identifiers

PMID39655539
PMCPMC11629101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.