Evidence map›Paper›PMID 39655502›Full record

ArticleChemPlusChem2025

Chemically Crosslinked Alginate Hydrogel with Polyaziridine: Effects on Physicochemical Properties and Promising Applications.

Chaehoon Lee, Giacomo Fiocco, Barbara Vigani, Teresa Recca, Chiara Milanese, Chiara Delledonne, Maurizio Licchelli, Silvia Rossi, Yongjae Chung, Francesca Volpi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemPlusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chaehoon LeeDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.ORCID https://orcid.org/0000-0003-2591-2471
Giacomo FioccoArvedi Laboratory of Non-invasive Diagnostics, University of Pavia, via Bell'Aspa 3, 26100, Cremona, Italy.ORCID https://orcid.org/0000-0002-1458-9640
Barbara ViganiDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.
Teresa ReccaDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.ORCID https://orcid.org/0000-0002-2000-7846
Chiara MilaneseDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.ORCID https://orcid.org/0000-0002-3763-6657
Chiara DelledonneArvedi Laboratory of Non-invasive Diagnostics, University of Pavia, via Bell'Aspa 3, 26100, Cremona, Italy.
Maurizio LicchelliDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.ORCID https://orcid.org/0000-0002-9276-1530
Silvia RossiDepartment of Drug Sciences, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.ORCID https://orcid.org/0000-0001-9511-3857
Yongjae ChungDepartment of Heritage Science and Technology Studies, Graduate School of Korea Heritage, Korea National University of Heritage, Buyeo, Chungcheongnam-Do, 33115, Korea.
Francesca VolpiArvedi Laboratory of Non-invasive Diagnostics, University of Pavia, via Bell'Aspa 3, 26100, Cremona, Italy.ORCID https://orcid.org/0000-0001-7067-1350
Maduka L WeththimuniDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.ORCID https://orcid.org/0000-0002-8936-0891
Marco MalagodiArvedi Laboratory of Non-invasive Diagnostics, University of Pavia, via Bell'Aspa 3, 26100, Cremona, Italy.ORCID https://orcid.org/0000-0003-4286-6331

Funding

Italian Ministry of Foreign Affairs and International Cooperation KR23GR07
6 · The paper itself

Abstract

Alginate biopolymer is widely employed in many industrial fields thanks to its pleasing features of biodegradability, biocompatibility, low toxicity, and relatively low cost. The gelling process of alginate with divalent cations is fairly simple and thus it is used as a versatile biomaterial to tailor the desired mechanical and moisture properties. This study focused on developing new gel formulations to enhance the properties of calcium-alginate hydrogel (CA). The newly synthesized hydrogels, referred to as CA-CHEM gels, were chemically cross-linked with different ratios of pentaerythritol tris[3-(1-aziridinyl)propionate] (PTAP) through the reaction between the carboxylic groups of alginate and aziridines of PTAP. The reaction was successfully monitored by NMR. The new CA-CHEM gels were chemically characterized using FTIR-ATR, while SEM analysis confirmed the changes in the porosity and homogeneity of the network. Additionally, thermogravimetric analyses and mechanical properties showed improvement in degradation stability and in structural strength, compared to plain CA, with an increasing PTAP content up to 1 % w/w. Finally, the new CA-CHEM gels effectively controlled water absorption and release. In particular, CA-CHEM-1 performed as the most controlled system, making it promising for delivering aqueous cleaning solutions on water-sensitive surfaces such as a wooden historical musical instrument.

Indexed as

Alginate hydrogelBiopolymerChemical crosslinkingGel applicationPolyaziridine

Identifiers

PMID39655502
PMCPMC11912103

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.