Evidence map›Paper›PMID 39655485›Full record

ArticleAntioxidants & redox signaling2025

Alterations in Mitochondrial Function in Pulmonary Vascular Diseases.

Samar Farha, Kewal Asosingh, Paul M Hassoun, John Barnard, Suzy Comhair, Andrew Reichard, Nicholas Wanner, Milena Radeva, Micheala A Aldred, Gerald J Beck and 16 more

Abstract read
In one paragraph

Article in Antioxidants & redox signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Samar FarhaIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0003-4800-8928
Kewal AsosinghIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Paul M HassounDivision of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA.
John BarnardIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Suzy ComhairIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Andrew ReichardIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Nicholas WannerIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Milena RadevaIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Micheala A AldredDepartment of Medicine, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA.
Gerald J BeckIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Erika Berman-RosenzweigDepartment of Pediatrics and Medicine, Columbia University, New York, New York, USA.
Barry A BorlaugDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
J Emanuel FinetHeart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Robert P FrantzDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Gabriele GrunigDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Anna R HemnesDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Nicholas HillDivision of Pulmonary, Critical Care, and Sleep Medicine, Tufts Medical Center, Boston, Massachusetts, USA.
Evelyn M HornDivision of Cardiology, Weill Cornell Medical Center, New York, New York, USA.
Christine JellisHeart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Jane A LeopoldDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Reena MehraDivision of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington, USA.
Margaret M ParkHeart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Franz P RischardDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, Arizona, USA.
W H Wilson TangIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Serpil C ErzurumIntegrated Hospital-Care Institute, Cleveland Clinic, Cleveland, Ohio, USA.
PVDOMICS Study Group

Funding

Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating CenterU01HL125177 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BECK, GERALD J, ERZURUM, SERPIL C. · 2014 to 2020
$20.0M
NITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3M
Intergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7M
PVDOMICS Defining the Future Fingerprints of Pulmonary Vascular DiseaseU01HL125218 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERMAN-ROSENZWEIG, ERIKA S., HORN, EVELYN · 2014 to 2018
$1.6M
Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics: Clinical Centers (CC) (U01).U01HL125205 · NHLBI · MAYO CLINIC ROCHESTER · PI FRANTZ, ROBERT PAUL · 2014 to 2018
$1.5M
A molecular phenotype of combined pulmonary hypertensionU01HL125212 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEMNES, ANNA R, NEWMAN, JOHN HUGHES · 2014 to 2018
$1.5M
Phenomic and genomic study to subphenotype Hispanics with pulmonary hypertensionU01HL125208 · NHLBI · UNIVERSITY OF ARIZONA · PI GARCIA, JOE G. N., RISCHARD, FRANZ P · 2014 to 2018
$1.5M
Hopkins Clinical Center for Pulmonary Vascular Disease Phenomics ProgramU01HL125175 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASSOUN, PAUL M., MATHAI, STEPHEN C · 2015 to 2019
$1.1M
NHLBI NIH HHS R01 HL060917NHLBI NIH HHS U01 HL125175NHLBI NIH HHS U01 HL125177NHLBI NIH HHS U01 HL125205NHLBI NIH HHS U01 HL125208NHLBI NIH HHS U01 HL125212NHLBI NIH HHS U01 HL125215NHLBI NIH HHS U01 HL125218
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hypertension, PulmonaryMitochondriaAdultArginineFemaleHumansMaleMembrane Potential, MitochondrialMetabolomicsMiddle AgedSuperoxidesArginineSuperoxidesarginine metabolismmitochondriapulmonary hypertensionsuperoxide productiontransmembrane potential

Identifiers

PMID39655485
PMCPMC12344126

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.