Evidence map›Paper›PMID 39655453›Full record

ArticleInternational journal of rheumatic diseases2024

Females With Axial Spondyloarthritis Have Longer Diagnostic Delay and Higher Burden of the Disease. Results From the International Map of Axial Spondyloarthritis (IMAS).

Victoria Navarro-Compán, Marco Garrido-Cumbrera, Denis Poddubnyy, Christine Bundy, Souzi Makri, José Correa-Fernández, Shashank Akerkar, Jo Lowe, Elie Karam, Fernando Sommerfleck

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in International journal of rheumatic diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria Navarro-CompánHospital Universitario La Paz, Madrid, Spain.
Marco Garrido-CumbreraHealth & Territory Research (HTR), Universidad de Sevilla, Seville, Spain.ORCID https://orcid.org/0000-0001-9727-1189
Denis PoddubnyyCharité-Universitätsmedizin Berlin, Berlin, Germany.
Christine BundyCardiff University, Cardiff, UK.
Souzi MakriCyprus League for People With Rheumatism (CYLPER), Nicosia, Cyprus.
José Correa-FernándezHealth & Territory Research (HTR), Universidad de Sevilla, Seville, Spain.
Shashank AkerkarMumbai Arthritis Clinic, Mumbai, India.
Jo LoweAxial Spondyloarthritis International Federation (ASIF), London, UK.
Elie KaramCanadian Spondylitis Association (CSA), Toronto, Canada.
Fernando SommerfleckSanatorio Julio Mendez, Buenos Aires, Argentina.

Funding

Novartis Pharma
6 · The paper itself

Abstract

backgroundTo assess gender differences in a large sample of patients included in the International Map of Axial Spondyloarthritis (IMAS) study from around the globe.

methodIMAS is a cross-sectional online survey (2017-2022) of 5557 unselected axSpA patients from 27 countries. The current analysis assessed differences between males and females for: sociodemographic, health behaviors, disease characteristics, patient-reported outcomes, mental comorbidities, and treatments. Univariable and multivariable logistic regression analysis was used to evaluate the relationship between gender and disease characteristics, patient-reported outcomes, comorbidities, and treatments.

resultsData from 5555 patients reporting gender were analyzed: 3492 from Europe, 769 from North America, 600 from Asia, 548 from Latin America, and 146 from Africa. Globally, 55.4% were females, with higher proportions in South Africa (82.2%) and lower in Asia (20.8%). Compared to males, a lower percentage of females smoked and consumed alcohol. The diagnostic delay was significantly longer (+2.4 years) in females, while the frequency of HLA-B27 positivity of axSpA was lower in females. The use of axSpA pharmacological treatment was more common in females with a higher proportion having ever taken nonsteroidal anti-inflammatory drugs (NSAIDs), conventional synthetic DMARDs (csDMARDs), and biologic DMARDs (bDMARDS).

conclusionsIdentifying the specific disease characteristics associated with gender in patients with axSpA may help to improve the diagnosis and management of the disease, and thereby reduce the disease burden for patients around the world.

Indexed as

Axial SpondyloarthritisDelayed DiagnosisAdultAntirheumatic AgentsComorbidityCost of IllnessCross-Sectional StudiesFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresRisk FactorsSex FactorsTime FactorsAntirheumatic Agentsaxial spondyloarthritisdiagnosticdisease burdengender

Identifiers

PMID39655453
PMCPMC11629135

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.