Evidence map›Paper›PMID 39655417›Full record

ArticleBiochemistry2025

Discovery of Cryptic Natural Products Using High-Throughput Elicitor Screening on Agar Media.

Seoung Rak Lee, Étienne Gallant, Mohammad R Seyedsayamdost

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Leveraging antibiotic hormesis for cryptic natural product discovery.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seoung Rak LeeDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Étienne GallantDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-4618-1794
Mohammad R SeyedsayamdostDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-2707-4854

Funding

Exploring a New Dimension of Microbial Secondary MetabolismR01GM140034 · NIGMS · PRINCETON UNIVERSITY · PI SEYEDSAYAMDOST, MOHAMMAD R · 2021 to 2024
$1.2M
From Genes to Molecules and Back: Expanding the Chemical Space of Microbial and Microbiome Natural ProductsR35GM152049 · NIGMS · PRINCETON UNIVERSITY · PI Mohammad R Seyedsayamdost · 2024 to 2026
$1.2M
NIGMS NIH HHS R01 GM140034NIGMS NIH HHS R35 GM152049
6 · The paper itself

Abstract

It is now well-established that microbial genomes carry sparingly expressed biosynthetic gene clusters (BGCs) that need to be induced in order to characterize their products. To do so, we herein subjected two well-known producers,

Indexed as

AgarBiological ProductsBurkholderiaHigh-Throughput Screening AssaysMultigene FamilyBurkholderia gladioliCulture MediaAgarBiological ProductsCulture Media

Identifiers

PMID39655417
PMCPMC12303134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.