ArticleHuman brain mapping2024
Changes in Functional Connectivity Relate to Modulation of Cognitive Control by Subthalamic Stimulation.
Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans.Nature neuroscience · 2026Article
- Dynamic Reconfiguration of Cognitive Networks and Recovery From Microlesion Effects in Parkinson's Disease: Insights From a Longitudinal fNIRS Study.CNS neuroscience & therapeutics · 2026Article
- Investigating changes of functional brain networks in painful temporomandibular disorders: a resting-state fMRI study.Journal of oral & facial pain and headache · 2026Article
- Subthalamic stimulation shifts brain network dynamics from extensive functional support to motor dominance in Parkinson's disease.NPJ Parkinson's disease · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Subthalamic (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) patients not only improves kinematic parameters of movement but also modulates cognitive control in the motor and non-motor domain, especially in situations of high conflict. The objective of this study was to investigate the relationship between DBS-induced changes in functional connectivity at rest and modulation of response- and movement inhibition by STN-DBS in a visuomotor task involving high conflict. During DBS ON and OFF conditions, we conducted a visuomotor task in 14 PD patients who previously underwent resting-state functional MRI (rs-fMRI) acquisitions DBS ON and OFF as part of a different study. In the task, participants had to move a cursor with a pen on a digital tablet either toward (automatic condition) or in the opposite direction (controlled condition) of a target. STN-DBS induced modulation of resting-state functional connectivity (RSFC) as a function of changes in behavior ON versus OFF DBS was estimated using link-wise network-based statistics. Behavioral results showed diminished reaction time adaptation and higher pen-to-target movement velocity under DBS. Reaction time reduction was associated with attenuated functional connectivity between cortical motor areas, basal ganglia, and thalamus. On the other hand, increased movement velocity ON DBS was associated with stronger pallido-thalamic connectivity. These findings suggest that decoupling of a motor cortico-basal ganglia network underlies impaired inhibitory control in PD patients undergoing subthalamic DBS and highlight the concept of functional network modulation through DBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.