ArticleCureus2024
The Use of Next-Generation Sequencing to Assist in the Diagnosis of Atypical Vasculitis.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vasculitis can be challenging to diagnose, especially when vessels of multiple sizes are affected and manifestations do not classically fit into defined rheumatic disease entities. We present the case of a 58-year-old Caucasian woman who presented with headache and altered mental status, with subsequent left-sided hemiparesis and hemispatial neglect eight days after a dental procedure. She was found to have extensive multi-focal ischemic infarctions secondary to vasculitis affecting multiple intracranial blood vessels. Subsequent imaging showed increasing involvement of intra-abdominal blood vessels. There was no evidence of endocarditis. Serologies for lupus and autoimmune rheumatologic diseases were unremarkable. Our suspicion was high for an infectious trigger of vasculitis. However, extensive conventional diagnostic testing, including multiple blood cultures and brain biopsy, did not reveal an underlying infectious etiology. The use of next-generation sequencing (NGS) of cell-free DNA from blood revealed the infectious pathogen
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