ArticleJournal of inflammation research2024
The Effect of Systemic Immune-Inflammatory Index (SII) and Prognostic Nutritional Index (PNI) in Early Gastric Cancer.
Article in Journal of inflammation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic significance of systemic immune-inflammation index in hepatocellular carcinoma: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Prognostic and clinicopathological value of the prognostic nutritional index in prostate cancer treated with androgen deprivation therapy: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Research status and hotspots of the systemic immune-inflammation index: A bibliometric analysis.Medicine · 2026Article
- A nutrition-focused model for predicting postoperative complications in locally advanced gastric cancer after neoadjuvant chemotherapy: a retrospective cohort study.BMC gastroenterology · 2026Article
- Radiomic subtypes predict survival and chemotherapy benefit in stage I lung adenocarcinoma: a multicenter study.Insights into imaging · 2026Article
- The role of hormonal and nutritional biomarkers in predicting immune checkpoint inhibitor efficacy: current limitations and future prospects.Frontiers in immunology · 2026Review
- Preoperative PNI-dNLR Score as Predicting Long-Term Survival in Older Adults Undergoing Radical Gastrectomy for Gastric Cancer.Clinical interventions in aging · 2026Article
- A Cohort Study on Systemic Immune-Inflammation Index and Its Longitudinal Change in Relation to Colorectal Adenoma Recurrence.Journal of inflammation research · 2026Article
- Specific diagnostic value of systemic immune-inflammation indices combined with nutritional and tumor markers in the stage diagnosis of pancreatic cancer: a retrospective cohort study.Frontiers in oncology · 2026Article
- Development and validation of a prognostic nutritional-inflammatory-immune score and web-based dynamic nomogram for gastric cancer following radical gastrectomy: a multicenter study.Frontiers in nutrition · 2026Article
- Systemic inflammatory indices and lung cancer risk by smoking and alcohol use in Korean men: A secondary dataset analysis of the Korean Cancer Prevention Study-II.Tobacco induced diseases · 2026Article
- Systemic Immune-Inflammation Index and Prognostic Nutritional Index as Predictors of Renal Survival in Crescentic Glomerulonephritis.International journal of general medicine · 2026Article
- Correlation analysis of clinical efficacy and prognosis of endoscopic submucosal dissection of early gastric cancer with peripheral blood indexes.Frontiers in oncology · 2026Article
- Article
- Comparative evaluation of composite inflammatory indices for predicting prostate cancer risk and mortality: a NHANES-based study with external validation.Frontiers in oncology · 2026Article
- Rheumatoid arthritis-associated interstitial lung disease: clinical predictive model and external validation.Respiratory research · 2025Article
- Interpretable machine learning analysis of clinicopathological and immunonutritional biomarkers for predicting lymph node metastasis in gastric cancer.Scientific reports · 2025Article
- Association between the systemic immune-inflammation index and mortality risk in myocardial infarction patients: a retrospective cohort study.European journal of medical research · 2025Article
- Clinical significance of systemic inflammation response index and platelet-lymphocyte ratio in patients with stage I-III gastric cancer.World journal of gastrointestinal surgery · 2025Article
- Value of the systemic immune inflammation index in predicting the efficacy of neoadjuvant chemotherapy in patients with gastric cancer: a multicenter retrospective clinical study.Journal of gastrointestinal oncology · 2025Article
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Abstract
Background: In recent years, the systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) have been considered potential predictors of survival outcomes in various solid tumors, including gastric cancer. However, there is a notable lack of research focusing on their prognostic implications specifically in the early stage of gastric cancer. This study aims to investigate the prognostic indicators of early gastric cancer (EGC), including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), SII, PNI, and lymph node metastasis (LNM). Methods: In this retrospective analysis, we examined 490 patients diagnosed with EGC (pT1Nx). The peripheral blood indices of interest were SII, PNI, PLR, and NLR. The receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC) were used to determine optimal cutoff values and prognostic efficacy for each parameter. Additionally, Kaplan-Meier survival curves and multivariate Cox regression models were utilized to delineate independent prognostic factors. Results: The optimal cutoff values for SII and PNI were determined as 613.05 and 42.21, respectively. Patients in the low SII (SII-L) group demonstrated significantly higher 5-year Disease-Free Survival (DFS) and Overall Survival (OS) rates of 94.7% and 96.2%, compared to the high SII (SII-H) group (DFS: 78.7%; OS: 81.9%), with both differences proving statistically significant (P < 0.001, P < 0.001). Similarly, patients in the high PNI (PNI-H) group showed superior 5-year DFS (93.3%) and OS rates (95.1%) versus the low PNI (PNI-L) group (DFS: 71.4%; OS: 74.3%), also demonstrating statistical significance (P < 0.001, P < 0.001). Multivariate analysis identified SII, PNI, and LNM as independent prognostic factors for EGC. A combined analysis of SII, PNI, and LNM yielded a C-index of 0.723 (P = 0.008). Conclusion: SII, PNI, and LNM are effective markers for predicting the survival outcomes of patients undergoing radical gastrectomy for EGC.
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