ArticleHeliyon2024
The maximum size of cell-aggregates is determined by the competition between the strain energy and the binding energy of cells.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of tissues and organs is affected by how cells interact with each other to form aggregates. Such an interaction is in turn determined by several different factors, such as inter-cellular attractive forces, cell motility, and the strain energy of cells. Here, we have used mathematical modelling and numerical simulations to explore how the interplay between these factors can influence the formation and stability of 2D cell aggregates. Cell aggregates were created by incrementally accumulating cells over an initial seed. The binding energy density of these aggregates was determined using the harmonic approximation and was integrated into a probabilistic model to estimate the maximum cluster size, beyond which the aggregate becomes unstable and breaks into smaller fragments. Our simulations reveal that the ratio of strain energy to internal adhesive energy (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.