Evidence map›Paper›PMID 39654135›Full record

ArticlePrion2024

Genetic assessment of apolipoprotein E polymorphism and PRNP genotypes in rapidly progressive dementias in Pakistan.

Urwah Rasheed, Minahil Khalid, Aneeqa Noor, Umar Saeed, Rizwan Uppal, Saima Zafar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prion, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Urwah RasheedDepartment of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology, Islamabad, Pakistan.
Minahil KhalidDepartment of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology, Islamabad, Pakistan.ORCID 0009-0006-4684-8455
Aneeqa NoorDepartment of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology, Islamabad, Pakistan.ORCID 0000-0001-8692-3161
Umar SaeedDepartment of Research and Development, Islamabad Diagnostic Center (IDC), Islamabad, Pakistan.ORCID 0000-0002-9740-0371
Rizwan UppalDepartment of Research and Development, Islamabad Diagnostic Center (IDC), Islamabad, Pakistan.ORCID 0000-0003-1599-651X
Saima ZafarDepartment of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology, Islamabad, Pakistan.ORCID 0000-0002-4261-0339

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapidly progressive dementias (RPDs) are a type of fatal dementias that cause rapid progression of neuronal dysfunction. This study aimed to assess the prevalence of APOE genotypes (ε2, ε3, ε4) and PRNP mutations (E200K, M129V) in the general population of Pakistan because of their association with RPDs, including Rapidly Progressive Alzheimer's Disease (rpAD) and Creutzfeldt-Jakob Disease (CJD). Blood samples (

Indexed as

Apolipoproteins EGenotypePrion ProteinsAgedAllelesAlzheimer DiseaseCreutzfeldt-Jakob SyndromeDementiaFemaleGene FrequencyHumansMaleMiddle AgedMutationPakistanPolymorphism, GeneticApolipoproteins EPrion ProteinsPRNP protein, humanAlzheimer’s diseaseCreutzfeldt-Jakob diseaseincidencerapidly progressive Alzheimer’s diseaserapidly progressive dementia

Identifiers

PMID39654135
PMCPMC11812391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.