ArticleMolecular and cellular pediatrics2024
Age-stratification reveals age-specific intestinal microbiota signatures in juvenile idiopathic arthritis.
Article in Molecular and cellular pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact ofFrontiers in cellular and infection microbiology · 2025Pooled it
- A Step-by-Step Guide to Successful Multiparametric Microbiota Flow Cytometry.Current protocols · 2026Article
- IgG4-related disease has a specific intestinal microbiota signature.EBioMedicine · 2026Article
- Composition of and changes in faecal microbiota in children diagnosed with oligoarticular juvenile idiopathic arthritis.Frontiers in medicine · 2026Article
- One-year follow-up of a short specific carbohydrate diet intervention in children with juvenile idiopathic arthritis: A retrospectively controlled study with focus on medical burden.Clinical rheumatology · 2025Article
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Authors and funding
18 authors.
Funding
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Abstract
objectiveJuvenile Idiopathic Arthritis (JIA) comprises diverse chronic inflammatory conditions driven by malfunction of the immune system. The intestinal microbiota is considered a crucial environmental factor correlating with chronic inflammatory diseases, and for JIA certain alterations in the microbiota have already been described.
methodsHere, we have characterized intestinal microbiota samples from 54 JIA patients and 38 pediatric healthy controls by conventional 16S rRNA sequencing and by single-cell analysis for phenotypic features by multi-parameter microbiota flow cytometry (mMFC), which complements the population-based taxonomic profiling with the characterization of individual bacterial cells.
resultsWe found age to be a crucial confounder in microbiota analyses of JIA patients. Age stratification revealed specific microbiota alterations neglected by the general comparison of JIA patients and pediatric controls.
conclusionAge groups presented distinct taxonomic profiles and microbiota phenotypic signatures which transitioned with age, highlighting changes in the microbiota-immune system interaction with age.
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