Evidence map›Paper›PMID 39653970›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2025

The anesthetic and recovery profiles of low-dose hypobaric mepivacaine and bupivacaine for spinal anesthesia in total hip and knee arthroplasty: a prospective observational study.

Joanne M H Tan, Wendy Wang, Takayuki Yoshida, Sara Abdullah, Jayanta Chowdhury, Ki Jinn Chin

Abstract readObservational Study
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Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Joanne M H TanDepartment of Anaesthesia, Pain and Hyperbaric Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia.
Wendy WangTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Takayuki YoshidaDepartment of Anesthesiology, Kansai Medical University Medical Center, Moriguchi, Osaka, Japan.
Sara AbdullahDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Jayanta ChowdhuryDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Ki Jinn ChinDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. gasgenie@gmail.com.ORCID 0000-0002-8339-3764

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSame-day mobilization and early hospital discharge is increasingly emphasized following hip and knee arthroplasty. One challenge of spinal anesthesia in this setting is achieving adequate block height while avoiding excessively large local anesthetic doses and prolonged motor and sensory blockade. Using a hypobaric local anesthetic solution is one potential strategy, as its intrathecal distribution can be reliably manipulated by patient positioning to achieve adequate block height independent of dose.

methodsWe conducted a prospective observational study to determine the clinical characteristics of spinal anesthesia with low-dose hypobaric mepivacaine and bupivacaine in patients undergoing hip and knee arthroplasty. Thirty patients scheduled for same-day discharge received 51 mg of hypobaric 1.5% mepivacaine and 30 patients scheduled for inpatient stay received 10 mg of hypobaric 0.33% bupivacaine.

resultsThe mean (standard deviation) time to achieve sensory blockade at or above L1 and T10 in the operative limb was 5.7 (1.8) and 7.3 (3.3) min with mepivacaine and 6.2 (2.6) and 8.1 (4.8) min with bupivacaine, respectively. Anesthesia was adequate for surgical commencement in all patients regardless of spinal injection level. Four patients required anesthetic supplementation for surgical completion. Sensory block duration at or above T10 and L1 in the operative limb was 97 (27) and 115 (37) min with mepivacaine and 127 (32) and 161 (34) min with bupivacaine, respectively. Motor function returned by 145 (37) and 217 (43) min in mepivacaine and bupivacaine groups, respectively.

conclusionThe anesthetic profiles of low-dose hypobaric mepivacaine and bupivacaine were favorable for fast-track hip and knee arthroplasty with short and predictable operating times.

Indexed as

Anesthesia, SpinalAnesthetics, LocalArthroplasty, Replacement, HipArthroplasty, Replacement, KneeBupivacaineMepivacaineAgedAged, 80 and overAnesthesia Recovery PeriodFemaleHumansMaleMiddle AgedProspective StudiesTime FactorsAnesthetics, LocalBupivacaineMepivacainebupivacainehip arthroplastyknee arthroplastymepivacainespinal anesthesia

Identifiers

PMID39653970

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.