Evidence map›Paper›PMID 39653960›Full record

ReviewMedical oncology (Northwood, London, England)2024

Metal-organic frameworks as nanoplatforms for combination therapy in cancer treatment.

Zainab Lafi, Sina Matalqah, Ebaa Abu-Saleem, Nisreen Asha, Hala Mhaidat, Sherine Asha, Lara Al-Nashash, Hussein S Janabi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zainab LafiPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, PO Box: 19328, Amman, Jordan. z.lafi@ammanu.edu.jo.
Sina MatalqahPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, PO Box: 19328, Amman, Jordan.
Ebaa Abu-SaleemPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, PO Box: 19328, Amman, Jordan.
Nisreen AshaThe University of Oklahoma Health Sciences, Oklahoma, USA.
Hala MhaidatKing Abdullah University Hospital, Irbid, Jordan.
Sherine AshaThe University of Jordan, Amman, Jordan.
Lara Al-NashashPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, PO Box: 19328, Amman, Jordan.
Hussein S JanabiPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, PO Box: 19328, Amman, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of nanotechnology into cancer treatment has revolutionized chemotherapy, boosted its effectiveness while reduced side effects. Among the various nanotherapeutic approaches, metal-organic frameworks (MOFs) stand out as promising carriers for targeted chemotherapy, with the added benefit of enabling combination therapies. MOFs, composed of metal ions or clusters linked by coordination bonds, tackle critical issues in traditional cancer treatments, such as poor stability, limited efficacy, and severe side effects. Their key advantages include customizable size and shape, diverse compositions, controlled porosity, large surface areas, ease of modification, and biocompatibility. This review highlights recent advancements in the use of MOFs for cancer therapy, showcasing their role in both monotherapies and combination strategies. Additionally, it explores the future potential and challenges of MOF-based platforms in tumor treatment.

Indexed as

Metal-Organic FrameworksNanoparticle Drug Delivery SystemNeoplasmsAnimalsAntineoplastic AgentsCombined Modality TherapyHumansAntineoplastic AgentsMetal-Organic FrameworksNanoparticle Drug Delivery SystemCancerChemotherapyCombinationDrug-DeliveryMOFsNanotechnologyOncology

Identifiers

PMID39653960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.