Evidence map›Paper›PMID 39653845›Full record

ArticleNature computational science2024

A scalable framework for learning the geometry-dependent solution operators of partial differential equations.

Minglang Yin, Nicolas Charon, Ryan Brody, Lu Lu, Natalia Trayanova, Mauro Maggioni

Abstract read
In one paragraph

Article in Nature computational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Neural Operator-enabled Topology-informed Evolutionary Strategy for PDE-Constrained Optimization.IEEE transactions on evolutionary computation : a publication of the IEEE Neural Networks Council · 2026
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  14. Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Minglang YinDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7861-350X
Nicolas CharonDepartment of Mathematics, University of Houston, Houston, TX, USA.
Ryan BrodyDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Lu LuDepartment of Statistics and Data Science, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5476-5768
Natalia TrayanovaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. ntrayanova@jhu.edu.ORCID http://orcid.org/0000-0002-8661-063X
Mauro MaggioniAlliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, USA. mauromaggionijhu@icloud.com.ORCID http://orcid.org/0000-0003-3258-9297

Funding

Artificial intelligence analysis of atrial remodeling evolution in patients with atrial fibrillation: Towards optimal ablation strategiesR01HL166759 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Eugene Kholmovski, David Spragg · 2023 to 2026
$3.2M
Heart Digital Twin Analysis of Arrhythmias due to Infiltrating AdiposityR01HL174440 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NATALIA A. TRAYANOVA · 2024 to 2026
$2.1M
National Science Foundation (NSF) DMS-1945224National Science Foundation (NSF) DMS-2436738NHLBI NIH HHS R01 HL166759NHLBI NIH HHS R01 HL174440United States Department of Defense | United States Air Force | AFMC | Air Force Office of Scientific Research (AF Office of Scientific Research) FA9550-20-1-0288United States Department of Defense | United States Air Force | AFMC | Air Force Office of Scientific Research (AF Office of Scientific Research) FA9550-21-1-0317United States Department of Defense | United States Air Force | AFMC | Air Force Office of Scientific Research (AF Office of Scientific Research) FA9550-23-1-0445U.S. Department of Energy (DOE) DE-SC0025592U.S. Department of Energy (DOE) DE-SC0025593U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL166759U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL174440
6 · The paper itself

Abstract

Solving partial differential equations (PDEs) using numerical methods is a ubiquitous task in engineering and medicine. However, the computational costs can be prohibitively high when many-query evaluations of PDE solutions on multiple geometries are needed. Here we aim to address this challenge by introducing Diffeomorphic Mapping Operator Learning (DIMON), a generic artificial intelligence framework that learns geometry-dependent solution operators of different types of PDE on a variety of geometries. We present several examples to demonstrate the performance, efficiency and scalability of the framework in learning both static and time-dependent PDEs on parameterized and non-parameterized domains; these include solving the Laplace equations, reaction-diffusion equations and a system of multiscale PDEs that characterize the electrical propagation on thousands of personalized heart digital twins. DIMON can reduce the computational costs of solution approximations on multiple geometries from hours to seconds with substantially less computational resources.

Identifiers

PMID39653845
PMCPMC11659174

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.