Evidence map›Paper›PMID 39653817›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Human dose-escalation study of PET imaging CD8

Yan Wang, Meng Zheng, Jun Zhao, Chao Wang, Shandong Zhao, Yicong Bian, Na Dai, Yushuang Zheng, Shibiao Sang, Linchuan Guo and 9 more

Registry-linked trialAbstract readClinical Trial, Phase I
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05126927 (A Study to Evaluate the Safety Tolerability, Radiation Absorbed Dose,Distribution, PET Imaging and Histological Expression of 68GA-Nodaga-SNA006 in Patients With Solid Tumors.), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05126927 early_phase1completednot on this map

A Study to Evaluate the Safety Tolerability, Radiation Absorbed Dose,Distribution, PET Imaging and Histological Expression of 68GA-Nodaga-SNA006 in Patients With Solid Tumors.

TypeinterventionalSponsorSmartNuclide BiopharmaRan2021 to 2022Enrolled11ConditionsSolid TumorArms68Ga-NODAGA-SNA006
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yan WangDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Meng ZhengDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Jun ZhaoDepartment of Thoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, China.
Chao WangSmart-Nuclide Biotech, No. 218 Xing-Hu Rd, Suzhou, Jiangsu, 215125, China.
Shandong ZhaoDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Yicong BianDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Na DaiDepartment of Nuclear Medicine, First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Yushuang ZhengDepartment of Pathology, First Affiliated Hospital of Soochow University, Suzhou, China.
Shibiao SangDepartment of Nuclear Medicine, First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Linchuan GuoDepartment of Pathology, First Affiliated Hospital of Soochow University, Suzhou, China.
Chenrong HuangDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Hua ZhangDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China.
Jiwei JiangDepartment of Nuclear Medicine, First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Chun XuDepartment of Thoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, China.
Qi ZhaoDepartment of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou, China.
Jiajun HanDepartment of Thoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou, China.
Tao XuSmart-Nuclide Biotech, No. 218 Xing-Hu Rd, Suzhou, Jiangsu, 215125, China. tao.xu@smartnucl.com.
Songbing QinDepartment of Radiation Oncology, First Affiliated Hospital of Soochow University, Suzhou, China. qin92244@163.com.
Liyan MiaoDepartment of Clinical Pharmacology, First Affiliated Hospital of Soochow University, Suzhou, China. miaolysuzhou@163.com.

Funding

Jiangsu Innovative and Enterpreneurial Talent Programme JSSCBS20211568Jiangsu Provincial Medical Key Discipline ZDXK202247Jiangsu Provincial Science and Technology Plan Special Fund BM2023003National Natural Science Foundation of China 82073337National Natural Science Foundation of China 82104318Natural Science Foundation for doctoral training program of the First Affiliated Hospital of Soochow University BXQN2023038Science and Technology Plan of Suzhou KJXW2023004Science and Technology Plan of Suzhou SKJYD2021159Science and Technology Plan of Suzhou SKJYD2021161
6 · The paper itself

Abstract

purposeA noninvasive method for evaluating the infiltration of CD8

methodsThis human dose-escalation PET imaging study involved eleven patients (lung cancer, 8; gastric carcinoma, 1; esophageal carcinoma, 2). Approximately 150 MBq of [

results[

conclusionThe use of [

trial registrationNCT05126927 (19 November 2021, retrospectively registered).

Indexed as

AcetatesCD8-Positive T-LymphocytesHeterocyclic Compounds, 1-RingNeoplasmsPositron-Emission TomographyPositron Emission Tomography Computed TomographySingle-Domain AntibodiesAdultAgedFemaleGallium RadioisotopesHumansMaleMiddle AgedTissue Distribution1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononaneAcetatesGallium RadioisotopesHeterocyclic Compounds, 1-RingSingle-Domain Antibodies[68Ga]Ga-NODAGA-SNA006CD8+ T cellClinical translationNanobodyPET/CT

Identifiers

PMID39653817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.