Evidence map›Paper›PMID 39653411›Full record

ArticleGut2025

Butyrate-producing

Zhuangzhuang Shi, Min Li, Chen Zhang, Hongwen Li, Yue Zhang, Lei Zhang, Xin Li, Ling Li, Xinhua Wang, Xiaorui Fu and 6 more

Abstract read
In one paragraph

Article in Gut, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Gut microbes · 2026
    Article
  2. Review
  3. Modulatory Effects ofNutrients · 2026
    Article
  4. Article
  5. Sodium butyrate induces apoptosis enhanced by JAK2 inhibitor Fedratinib in NK/T-cell lymphoma cell.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Indole-3-Carbaldehyde fromResearch (Washington, D.C.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhuangzhuang Shi *Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Min Li *Department of Bioinformatics and Systems Biology, Huazhong University of Science and Technology, Wuhan, China.
Chen Zhang *Lymphoma Diagnosis and Treatment Centre of Henan Province, Zhengzhou, Henan, China.
Hongwen LiLymphoma Diagnosis and Treatment Centre of Henan Province, Zhengzhou, Henan, China.
Yue ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Lei ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xin LiDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Ling LiDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xinhua WangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xiaorui FuDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhenchang SunDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xudong ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Li TianDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Mingzhi ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China fcclizm@zzu.edu.cn weihuachen@hust.edu.cn mingzhi_zhang1@163.com.
Wei-Hua ChenDepartment of Bioinformatics and Systems Biology, Huazhong University of Science and Technology, Wuhan, China fcclizm@zzu.edu.cn weihuachen@hust.edu.cn mingzhi_zhang1@163.com.ORCID http://orcid.org/0000-0001-5160-4398
Zhaoming LiDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China fcclizm@zzu.edu.cn weihuachen@hust.edu.cn mingzhi_zhang1@163.com.ORCID http://orcid.org/0000-0002-3274-2864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNatural killer/T-cell lymphoma (NKTCL) is a highly aggressive malignancy with a dismal prognosis, and gaps remain in understanding the determinants influencing disease outcomes.

objectiveTo characterise the gut microbiota feature and identify potential probiotics that could ameliorate the development of NKTCL.

designThis cross-sectional study employed shotgun metagenomic sequencing to profile the gut microbiota in two Chinese NKTCL cohorts, with validation conducted in an independent Korean cohort. Univariable and multivariable Cox proportional hazards analyses were applied to assess associations between identified marker species and patient outcomes. Tumour-suppressing effects were investigated using comprehensive in vivo and in vitro models. In addition, metabolomics, RNA sequencing, chromatin immunoprecipitation sequencing, Western blot analysis, immunohistochemistry and lentiviral-mediated gene knockdown system were used to elucidate the underlying mechanisms.

resultsWe first unveiled significant gut microbiota dysbiosis in NKTCL patients, prominently marked by a notable reduction in

conclusionThese findings uncover a distinctive gut microbiota profile in NKTCL and provide a novel perspective on leveraging the therapeutic potential of

Indexed as

ButyratesFaecalibacterium prausnitziiGastrointestinal MicrobiomeJanus KinasesSTAT Transcription FactorsAnimalsCell Line, TumorCross-Sectional StudiesDysbiosisFemaleHumansMaleMiceMiddle AgedProbioticsSignal TransductionButyratesJanus KinasesSTAT Transcription FactorsBUTYRATEINTESTINAL MICROBIOLOGYLYMPHOMAPROBIOTICS

Identifiers

PMID39653411
PMCPMC12013593

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.