Evidence map›Paper›PMID 39653040›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2025

Chronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.

Alice P Sowton, Lorenz M W Holzner, Fynn N Krause, Ruby Baxter, Gabriele Mocciaro, Dominika K Krzyzanska, Magdalena Minnion, Katie A O'Brien, Matthew C Harrop, Paula M Darwin and 5 more

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Science advances · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alice P SowtonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-3718-7783
Lorenz M W HolznerDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Fynn N KrauseDepartment of Biochemistry and Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom.
Ruby BaxterDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.ORCID 0009-0009-0926-812X
Gabriele MocciaroDepartment of Biochemistry and Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom.
Dominika K KrzyzanskaDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Magdalena MinnionClinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0001-9239-5764
Katie A O'BrienDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Matthew C HarropDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Paula M DarwinDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Benjamin D ThackrayDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Michele VaccaDepartment of Biochemistry and Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-1973-224X
Martin FeelischClinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0003-2320-1158
Julian L GriffinDepartment of Biochemistry and Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom.
Andrew J MurrayDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-0929-9315

Funding

Biotechnology and Biological Sciences Research Council BB/M011194/1British Heart Foundation (BHF) FS/17/61/33473British Heart Foundation (BHF) FS/18/56/34177British Heart Foundation (BHF) FS/4yPhD/F/20/34124British Heart Foundation (BHF) FS/4yPhD/F/21/34156Evelyn Trust 16/33Medical Research Council MC_PC_13030Medical Research Council MC_UP_A090_1006Medical Research Council MR/P011705/1Medical Research Council MR/P01836X/1Research Councils UK EP/E500552/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M011194/1UKRI | Medical Research Council (MRC) MC PC 13030UKRI | Medical Research Council (MRC) MC UP A90 1006Wellcome Trust 220033Wellcome Trust (WT) 220033/Z/19/Z
6 · The paper itself

Abstract

Inorganic nitrate (NO

Indexed as

Dietary SupplementsDiet, High-FatDisease ProgressionMice, Inbred C57BLNitratesObesityAnimalsLiverMaleMetabolic SyndromeMiceMyocardiumNitratessodium nitrateinorganic nitratemetabolic dysfunction-associated steatotic liver diseasemetabolismmitochondriaobesity

Identifiers

PMID39653040
PMCPMC7617849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.