ArticleNeonatology2025
Rationale and Approach to Evaluating Interventions for Newborn Care in Low- and Middle-Income Countries.
Article in Neonatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Postnatal interventions to support newborn survival: updates for the Lives Saved Tool.Journal of global health · 2026Pooled it
- Post-Asphyxial Aftercare and Management of Neonates in Low- and Middle-Income Countries: A Systematic Evidence Synthesis.Neonatology · 2025Pooled it
- The Care of Preterm and Term Newborns with Respiratory Conditions: A Systematic Synthesis of Evidence from Low- and Middle-Income Countries.Neonatology · 2025Pooled it
- Effectiveness of Neonatal Resuscitation Training Programs, Implementation, and Scale-Up in Low- and Middle-Income Countries.Neonatology · 2025Pooled it
- Prevention and Treatment of Neonatal Infections in Facility and Community Settings of Low- and Middle-Income Countries: A Descriptive Review.Neonatology · 2025Pooled it
- Pooled it
- Interventions to Prevent and Manage Infections in Pregnancy.Neonatology · 2025Pooled it
- Nutritional Management of Low Birth Weight and Preterm Infants in Low- and Low Middle-Income Countries.Neonatology · 2025Pooled it
- The Effectiveness of Regionalization of Perinatal Care and Specific Facility-Based Interventions: A Systematic Review.Neonatology · 2025Pooled it
- Antenatal interventions to support newborn survival: updates for the Lives Saved Tool.Journal of global health · 2026Article
- Antenatal Care Strategies to Improve Perinatal and Newborn Outcomes.Neonatology · 2025Review
- Neonatal Care in Low- and Middle-Income Countries: A Fresh Look.Neonatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe neonatal period is the most vulnerable time in a child's life, contributing to almost half of all deaths in children under 5 years. Many of these deaths are preventable and are mainly caused by preterm birth, birth asphyxia, or serious infections. Over the past decade, the evidence base for interventions to prevent and manage these causes of neonatal mortality and morbidity in low- and middle-income countries (LMICs) has expanded significantly. This growth calls for a comprehensive and systematic approach to synthesizing the available evidence. This paper describes the methodological approach taken before and during the conduct of the systematic overviews and reviews described in the online supplementary material (for all online suppl. material, see <ext-link ext-link-type="doi" xlink:href="https://doi.org/10.1159/000542754" xmlns:xlink="http://www.w3.org/1999/xlink">https://doi.org/10.1159/000542754</ext-link>).
methodsAlongside consultation with a newborn technical advisory group, the overall evidence synthesis approach began with an extensive literature-scoping exercise to establish a universe of interventions that were relevant to neonatal health and survival and to identify the associated systematic reviews examining their effectiveness. Three main approaches were taken to synthesize the evidence based on the availability of prior evidence. New systematic reviews were conducted for topics lacking an existing comprehensive synthesis. Existing systematic reviews with search dates prior to 2020 were updated. High-quality, up-to-date systematic reviews were used without modification. In all cases, trial data from studies conducted in LMICs were sought and prioritized for analysis.
conclusionA comprehensive approach to summarizing the best available evidence for newborn intervention effectiveness is described.
introductionThe neonatal period is the most vulnerable time in a child's life, contributing to almost half of all deaths in children under 5 years. Many of these deaths are preventable and are mainly caused by preterm birth, birth asphyxia, or serious infections. Over the past decade, the evidence base for interventions to prevent and manage these causes of neonatal mortality and morbidity in low- and middle-income countries (LMICs) has expanded significantly. This growth calls for a comprehensive and systematic approach to synthesizing the available evidence. This paper describes the methodological approach taken before and during the conduct of the systematic overviews and reviews described in the online supplementary material (for all online suppl. material, see <ext-link ext-link-type="doi" xlink:href="https://doi.org/10.1159/000542754" xmlns:xlink="http://www.w3.org/1999/xlink">https://doi.org/10.1159/000542754</ext-link>).
methodsAlongside consultation with a newborn technical advisory group, the overall evidence synthesis approach began with an extensive literature-scoping exercise to establish a universe of interventions that were relevant to neonatal health and survival and to identify the associated systematic reviews examining their effectiveness. Three main approaches were taken to synthesize the evidence based on the availability of prior evidence. New systematic reviews were conducted for topics lacking an existing comprehensive synthesis. Existing systematic reviews with search dates prior to 2020 were updated. High-quality, up-to-date systematic reviews were used without modification. In all cases, trial data from studies conducted in LMICs were sought and prioritized for analysis.
conclusionA comprehensive approach to summarizing the best available evidence for newborn intervention effectiveness is described.
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