ArticleDermatology practical & conceptual2024
Serum Biomarkers IL-6 and HIF-1α in Rosacea: Assessing Their Significance in Disease Pathogenesis and Telangiectasia Formation.
Article in Dermatology practical & conceptual, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Mechanisms in the Etiopathology of Rosacea-Systematic Review.International journal of molecular sciences · 2025Pooled it
- Gut microbiota dysbiosis at the interface of neuropsychiatric disorders and their dermatological comorbidities.Gut microbes · 2025Review
- Emulgel Containing Metronidazole and Clindamycin for the Treatment of Rosacea.Pharmaceutics · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRosacea, a chronic inflammatory disease primarily affecting the central area of the face, is a complex condition whose mechanisms are still not fully understood. However, research has indicated a positive correlation between two molecules: hypoxia-inducible factor-1α (HIF-1α) and interleukin-6 (IL-6). The levels of HIF-1α in rosacea patients have yet to be assessed.
objectivesThe aim of this study was to assess the levels of HIF-1α and IL-6 in patients with rosacea in relation to both the severity of the disease and the primary and secondary clinical manifestations of the condition.
methodsThe study included patients diagnosed with rosacea and sex-and age-matched healthy controls (N=40, N=40). Serum HIF-1α and IL-6 levels were quantified using enzyme-linked immunosorbent assay (ELISA).
resultsCompared to the control group, the patient group had significantly elevated serum levels of HIF-1α and IL-6. A positive correlation was found between the level of HIF-1α and the severity of the disease (r=0.374, P=0.017); furthermore, a significant association was observed between the presence of telangiectasia, one of the primary manifestations, and HIF-1α (z=2.401, P=0.016).
conclusionThe significantly elevated levels of IL-6 and HIF-1α in patients with rosacea compared to the control group support the hypothesis that these molecules play a role in the pathogenesis of the disease. The correlation between HIF-1α and the severity of the disease, and its significant elevation in patients with telangiectasia, suggest its potential involvement in the pathogenesis of the disease, particularly in the formation of telangiectasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.