ArticleJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2024
Outcomes After Total Knee Arthroplasty in Patients With Autism: A Retrospective Database Study.
Article in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Postoperative Complications in Patients With Sickle Cell Disease After Total Shoulder Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Following posterior spinal fusion for adolescent idiopathic scoliosis, patients with asthma are at increased odds of pulmonary adverse events.North American Spine Society journal · 2026Article
- Postoperative complications after anterior cervical discectomy and fusion in patients with versus without carotid artery stenosis.North American Spine Society journal · 2026Article
- Correlation of Fellowship Training With Clinical Outcomes following Total Knee Arthroplasty: Complications, Readmissions, and Implant Survival.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder associated with osteoarthritis for which total knee arthroplasty (TKA) may be considered. The safety and efficacy of TKA in patients with ASD had been poorly characterized.
methodsTotal knee arthroplasty patients were identified using the M157 PearlDiver database. Patients with autism spectrum disorder were matched 1:4 with control TKA patients based on age, sex, and Elixhauser Comorbidity Index (ECI). 90-day adverse events were compared by multivariable regression, controlling for age, sex, and ECI. 5-year rates of revision were compared using Kaplan-Meier survival analyses.
resultsOf 1,194,063 TKA patients, ASD was identified in 352 (0.02%). Patients with autism spectrum disorder were younger (60.0 vs. 65.8 years, P < 0.001) with higher ECIs (7.8 vs. 4.2, P < 0.001) than control patients. Patients with autism spectrum disorder had higher odds of aggregated adverse events driven by sepsis (odds ratio [OR] 3.11), pneumonia (OR 3.55), and urinary tract infection (OR 3.02) (P < 0.0036 for each). 5-year revision rates were not significantly different for the matched cohorts (P = 0.8000).
conclusionTotal knee arthroplasty patients with ASD had elevated odds of several infectious adverse events and may warrant additional perioperative precautions. No notable differences were observed in most adverse outcomes investigated, nor in 5-year implant survival, suggesting that patients with ASD can safely be considered for TKA.
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