ArticleDiabetes2025
Adipose Tissue Biology and Effect of Weight Loss in Women With Lipedema.
Article in Diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03271034 (Effect of Weight Loss on Body Composition and Metabolic Function in Women With Lipedema), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Weight Loss on Body Composition and Metabolic Function in Women With Lipedema
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- GLP-1 and GLP-1/GIP receptor agonist medication use and self-reported outcomes in individuals with lipedema: Results from a large online survey.Obesity pillars · 2026Article
- Current Evidence-Based Clinical Nutritional Approaches in Lipedema: A Scoping Review.Nutrition reviews · 2026Article
- Reduced Serum Endostatin in Premenopausal Women with Lipedema Suggests Altered Vascular Homeostasis.Diseases (Basel, Switzerland) · 2026Article
- ADAR1 Controls Macrophage Scavenging and Lipid-Buffering Programs in Metabolic Tissues.European journal of immunology · 2026Article
- Moderate weight loss decreases lipedema-affected body fat mass in a woman who is lean with lipedema.JCEM case reports · 2026Article
- Dietary Inflammatory Index and Mediterranean Diet Score are associated with systemic inflammation in women with lipedema.International journal of obesity (2005) · 2026Article
- Unraveling lipedema: comprehensive insights and the path to future discoveries.npj metabolic health and disease · 2026Review
- Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam.Nature communications · 2026Article
- Distinct systemic metabolic signatures in premenopausal women with lipedema revealed by composite indices.Frontiers in endocrinology · 2026Article
- Glucose and insulin dynamics following low-carbohydrate and low-fat diets in females with lipedema and obesity.Frontiers in cell and developmental biology · 2026Article
- Impact of Pycnogenol® Use in the Treatment of Patients With Lipedema: A Randomized Controlled Trial.Cureus · 2025Article
- Nutritional Approaches and Supplementation in Lipedema Management: A Narrative Review of Current Evidence.Current nutrition reports · 2025Review
- Article
- Therapeutic Applications of Ketogenic Diets in Lipedema: A Narrative Review of Current Evidence.Current obesity reports · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Lipedema is a lipodystrophic disease that is typically characterized by a marked increase in lower-body subcutaneous adipose tissue that is purported to have increased inflammation and fibrosis, have impaired microvascular/lymphatic circulation, and be resistant to reduction by weight loss therapy. However, these outcomes have not been adequately studied. We evaluated body composition, insulin sensitivity, metabolic health, and adipose tissue biology in women with obesity and lipedema (Obese-LIP) before and after moderate (∼9%) diet-induced weight loss. At baseline, people with Obese-LIP had ∼23% greater leg fat mass, ∼11% lower android-to-gynoid ratio, and ∼48% greater insulin sensitivity (all P < 0.05) than women matched on age, BMI, and whole-body adiposity. In Obese-LIP, macrophage content and expression of genes involved in inflammation and fibrosis were greater, whereas lymph/angiogenesis-related genes were lower in thigh than abdominal subcutaneous adipose tissue. Weight loss improved insulin sensitivity and decreased total fat mass, with similar relative reductions in abdominal and leg fat masses, but without changes in markers of inflammation and fibrosis. These results demonstrate that affected adipose tissue in women with lipedema is characterized by increased inflammation and fibrogenesis, and alterations in lymphatic and vascular biology. Moderate diet-induced weight loss improves metabolic function and decreases lower-body adipose tissue mass. ARTICLE HIGHLIGHTS: We sought to increase our understanding of the pathophysiology of lipedema and the effects of weight loss. We examined whether there are differences in upper- and lower-body adipose tissue biology in lipedema and whether adipose tissue is affected by weight loss. Women with obesity and lipedema have decreased expression of genes related to lymphatic/vascular function and increased expression of genes related to fibrosis and inflammation in thigh compared with abdominal subcutaneous adipose tissue; weight loss increased insulin sensitivity and decreased leg fat but did not affect adipose tissue inflammation or fibrosis. Weight loss should be the first-line therapy for women with obesity and lipedema.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.