Evidence map›Paper›PMID 39652223›Full record

ArticleMedical molecular morphology2025

Clinicopathological significance of sulfite oxidase expression in surgically resected lung adenocarcinoma.

Saeko Tokisawa, Reiichiro Kondo, Masamichi Nakayama, Sachiko Ogasawara, Kenta Murotani, Masahiro Mitsuoka, Tomoaki Hoshino, Hirohisa Yano, Jun Akiba

Abstract read
PubMed Publisher
In one paragraph

Article in Medical molecular morphology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saeko TokisawaDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Reiichiro KondoDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan. kondou_reiichirou@kurume-u.ac.jp.ORCID http://orcid.org/0000-0002-2769-7392
Masamichi NakayamaDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Sachiko OgasawaraDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Kenta MurotaniSchool of Medical Technology, Kurume University, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Masahiro MitsuokaDepartment of Surgery, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Tomoaki HoshinoDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Hirohisa YanoClinical Laboratory, Saiseikai Futsukaichi Hospital, 3-13-1, Yu-Machi, Chikushino, Fukuoka, 818-8516, Japan.
Jun AkibaDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe coenzyme sulfite oxidase (SUOX), located in mitochondria, plays a role in redox and metabolism. Its expression has been associated with cancer progression and prognosis. Lung cancer has a high incidence rate and poor prognosis. We aim to clarify its expression in lung adenocarcinomas and investigated the utility of SUOX expression as a recurrence factor in operable lung adenocarcinoma.

methodsWe used 60 formalin-fixed paraffin-embedded samples of operable primary lung adenocarcinoma between 2017 and 2018 to immunohistochemically assess SUOX expression levels. Patients were classified into a high or low SUOX expression group, and the associations of SUOX expression with clinicopathological findings and recurrence were analyzed.

resultsWe revealed that high SUOX expression was significantly (p < 0.05) associated with sex, low Brinkman index, histological type, histological grade and positive for epidermal growth factor receptor (EGFR) mutation. High SUOX expression (HR = 10.218, 95% CI 1.758‒59.376, p = 0.0096) and pathological Stage (HR = 7.538, 95% CI 1.95‒29.14, p = 0.0034) were independently associated with relapse free survival.

conclusionHigh SUOX expression may be a new indicator of recurrence risk in surgically resected lung adenocarcinomas.

Indexed as

Adenocarcinoma of LungLung NeoplasmsSulfite OxidaseAdultAgedBiomarkers, TumorErbB ReceptorsFemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm Recurrence, LocalOxidoreductases Acting on Sulfur Group DonorsPrognosisBiomarkers, TumorErbB ReceptorsOxidoreductases Acting on Sulfur Group DonorsSulfite OxidaseSUOX protein, humanAdenocarcinomaEpidermal growth factor receptorLung cancerRecurrenceSulfite oxidaseSUOX

Identifiers

PMID39652223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.