Evidence map›Paper›PMID 39651963›Full record

ArticleeLife2024

Unified bursting strategies in ectopic and endogenous

Augusto Berrocal, Nicholas C Lammers, Hernan G Garcia, Michael B Eisen

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Regulation of Transcriptional Bursting and Spatial Patterning in EarlybioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Unified bursting strategies in ectopic and endogenousbioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Augusto BerrocalDepartment of Molecular & Cell Biology, University of California at Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-6506-9071
Nicholas C LammersBiophysics Graduate Group, University of California at Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0001-6832-6152
Hernan G GarciaDepartment of Molecular & Cell Biology, University of California at Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-5212-3649
Michael B EisenDepartment of Molecular & Cell Biology, University of California at Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-7528-738X

Funding

GENOMICST32HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN, Daniel Soleyman Rokhsar · 2000 to 2026
$13.5M
Lighting Up the Central Dogma in Embryonic DevelopmentDP2HD094655 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI GARCIA, HERNAN GUSTAVO · 2017 to 2017
$2.4M
Predictive understanding of the temporal control of transcription in Drosophila developmentR01GM139913 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GARCIA, HERNAN GUSTAVO · 2021 to 2024
$1.2M
In vivo mechanisms of Dorsal-mediated transcriptional control in developmentR01GM152815 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GARCIA, HERNAN GUSTAVO · 2024 to 2024
$306k
NHGRI NIH HHS T32 HG000047NICHD NIH HHS DP2 HD094655NIGMS NIH HHS R01 GM139913NIGMS NIH HHS R01 GM152815NIH Genomics and Computational Biology Training Grant 5T32HG000047-18NIH R01 Award R01GM139913NIH R01 Award R01GM152815
6 · The paper itself

Abstract

Transcription often occurs in bursts as gene promoters switch stochastically between active and inactive states. Enhancers can dictate transcriptional activity in animal development through the modulation of burst frequency, duration, or amplitude. Previous studies observed that different enhancers can achieve a wide range of transcriptional outputs through the same strategies of bursting control. For example, in Berrocal et al., 2020, we showed that despite responding to different transcription factors, all

Indexed as

Drosophila melanogasterDrosophila ProteinsEnhancer Elements, GeneticAnimalsEctopic Gene ExpressionEmbryo, NonmammalianGene Expression Regulation, DevelopmentalHomeodomain ProteinsPromoter Regions, GeneticTranscription FactorsTranscription, GeneticDrosophila Proteinseve protein, DrosophilaHomeodomain ProteinsTranscription Factorschromosomesdevelopmentdevelopmental biologyD. melanogasterenhancersgene expressionimagingpatterningtranscription

Identifiers

PMID39651963
PMCPMC11627552

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.