Evidence map›Paper›PMID 39651958›Full record

ArticleJournal of the American Chemical Society2024

Selective Biofilm Inhibition through Mucin-Inspired Engineering of Silk Glycopolymers.

Caroline Andrea Werlang, Jugal Kishore Sahoo, Gerado Cárcarmo-Oyarce, Corey Stevens, Deniz Uzun, Rachel Putnik, Onur Hasturk, Jaewon Choi, David L Kaplan, Katharina Ribbeck

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caroline Andrea WerlangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Jugal Kishore SahooDepartment of Biomedical Engineering, Science and Technology Center, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0000-0003-2503-9115
Gerado Cárcarmo-OyarceDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Corey StevensDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Deniz UzunDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Rachel PutnikDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Onur HasturkDepartment of Biomedical Engineering, Science and Technology Center, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0000-0002-0030-8967
Jaewon ChoiDepartment of Biomedical Engineering, Science and Technology Center, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0000-0002-2710-1085
David L KaplanDepartment of Biomedical Engineering, Science and Technology Center, Tufts University, Medford, Massachusetts 02155, United States.ORCID 0000-0002-9245-7774
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-8260-338X

Funding

Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
NIBIB NIH HHS P41 EB027062
6 · The paper itself

Abstract

Mucins are key components of innate immune defense and possess remarkable abilities to manage pathogenic microbes while supporting beneficial ones and maintaining microbial homeostasis at mucosal surfaces. Their unique properties have garnered significant interest in developing mucin-inspired materials as novel therapeutic strategies for selectively controlling pathogens without disrupting the overall microbial ecology. However, natural mucin production is challenging to scale, driving the need for simpler materials that reproduce mucin's bioactivity. In this work, we generated silk-based glycopolymers with different monosaccharides (GalNAc, GlcNAc, NeuNAc, GlcN, and GalN) and different grafting densities. Using the oral cavity as a model system, we treated

Indexed as

BiofilmsMucinsSilkStreptococcus mutansHumansStreptococcusStreptococcus sanguisMucinsSilk

Identifiers

PMID39651958
PMCPMC11996083

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.