Evidence map›Paper›PMID 39651910›Full record

ArticleAntimicrobial agents and chemotherapy2025

Contribution of telacebec to novel drug regimens in a murine tuberculosis model.

Oliver D Komm, Sandeep Tyagi, Andrew Garcia, Deepak Almeida, Yong Chang, Si-Yang Li, Jennie Ruelas Castillo, Paul J Converse, Todd Black, Nader Fotouhi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The role of cytochrome bcNature communications · 2025
    Article
  5. A Telacebec-Shaped Puzzle Piece in the Treatment of Mycobacterial Diseases.American journal of respiratory and critical care medicine · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Oliver D KommCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
Sandeep TyagiCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
Andrew GarciaCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
Deepak AlmeidaCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
Yong ChangCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
Si-Yang LiCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
Jennie Ruelas CastilloCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
Paul J ConverseCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
Todd BlackTB Alliance, New York, New York, USA.
Nader FotouhiTB Alliance, New York, New York, USA.
Eric L NuermbergerCenter for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-1440-9889

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical efficacy of combination drug regimens containing the first-generation diarylquinoline (DARQ) bedaquiline in the treatment of multidrug-resistant tuberculosis has validated ATP synthesis as a vulnerable pathway in

Indexed as

Antitubercular AgentsDiarylquinolinesDisease Models, AnimalMice, Inbred BALB CMycobacterium tuberculosisAnimalsClofazimineDrug Therapy, CombinationFemaleImidazolesMiceMicrobial Sensitivity TestsPiperidinesPyridinesThiophenesTuberculosis, Multidrug-ResistantAntitubercular AgentsbedaquilineClofazimineDiarylquinolinesImidazolesPiperidinesPyridinestelacebecThiophenesclofaziminediarylquinolineH37RvHN878mouseQ203telacebectuberculosis

Identifiers

PMID39651910
PMCPMC11838007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.