SynthesisFrontiers in public health2024
Depression among keratoconus patients: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beyond Vision: Unveiling the Psychiatric Dimensions of Keratoconus.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Association between attention deficit hyperactivity disorder and keratoconus.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2026Article
- Article
- Interventional Keratoconus Management: The Critical Imperative for Early Detection and Treatment.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Capacity of health facilities to diagnose and manage keratoconus: a Kilimanjaro region case study.International ophthalmology · 2025Article
- Quality of Life Enhancement After Penetrating Keratoplasty in Keratoconus: A Vision-Related Functional Perspective.Journal of clinical medicine · 2025Article
- Keratoconus: The Local Manifestation of a Systemic Disease?Journal of clinical medicine · 2025Review
- Correlation of tear cortisol levels with morphological and biomechanical parameters of keratoconus.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Keratoconus (KC) is a chronic corneal disease that typically presents in early adulthood, and may potentially result in poor mental health in affected individuals. The evidence regarding the association of depression with KC is controversial. Hence, we investigated the association between depression and KC via a systematic review and meta-analysis. Methods: Five electronic medical databases (PubMed, Scopus, PsycINFO, Web of Science, and CINAHL Complete) were systematically queried for English-language records from their inception to January 8, 2024. We include observational studies that measured the risk of depression or compared depression scores in KC patients in comparison to healthy ones. The Newcastle-Ottawa Quality Assessment Scale was utilized to assess bias risk in the included studies. Random-effect modeling was applied for meta-analysis (STATA-17). Results: Out of the 159 documents retrieved, seven articles were deemed relevant after screening. An analysis involving 83 KC patients and 3,186 controls indicated that KC participants had significantly higher depression scores [SMD: 0.71 [0.31, 1.11]; Conclusion: While KC patients exhibit significantly higher depression scores compared to controls, a meta-analysis indicates no increased overall risk of depression among KC patients. These findings highlight the complexity of the relationship between keratoconus and mental health, warranting further investigation. Systematic review registration: PROSPERO, identifier, CRD42024502247, available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024502247.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.