ArticleCurrent opinion in biomedical engineering2019
New optical methods for detecting monoamine neuromodulators.
Article in Current opinion in biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A Molecular Landscape of Mouse Hippocampal Neuromodulation.Frontiers in neural circuits · 2022Article
- A Bright and Colorful Future for G-Protein Coupled Receptor Sensors.Frontiers in cellular neuroscience · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Monoamine neuromodulators such as dopamine, norepinephrine, serotonin (5-HT), octopamine, and tyramine are signaling molecules in the nervous system, where they play critical roles in both health and disease. Given the complex spatiotemporal dynamics, similar structural features, and multiple receptors, studying their dynamics has been limited using conventional methods such as microdialysis and electrochemistry. However, recent advances in optics have facilitated the development of imaging-based detection methods. In this review, we summarize current detecting approaches for specific monoamines, emphasizing their design strategies, detection properties, applications, and limitations. We highlight the genetically encoded GPCR-based sensors for DA and NE, which have high signal-to-noise ratio, selectivity and can be used
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