Evidence map›Paper›PMID 39651332›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Heterogeneity of aerobic fitness changes with exercise training in progressive multiple sclerosis: Secondary, exploratory analysis of data from the CogEx trial.

Robert W Motl, Brian M Sandroff, Roberto S Hernandez, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Robert W MotlDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-5894-2290
Brian M SandroffKessler Foundation, West Orange, NJ, USA.ORCID https://orcid.org/0000-0002-2013-7632
Roberto S HernandezDepartment of Neurology, Section on Statistical Planning and Analysis, UT Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0003-3143-682X
Maria Pia AmatoDepartment NEUROFARBA, Section Neurosciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-3325-3760
Giampaolo BrichettoScientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Genoa, Italy.ORCID https://orcid.org/0000-0003-2026-3572
Jeremy ChatawayQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Nancy D ChiaravallotiKessler Foundation, West Orange, NJ, USA.ORCID https://orcid.org/0000-0003-2943-7567
Gary CutterDepartment of Biostatistics, University of Alabama, Birmingham, AL, USA.ORCID https://orcid.org/0000-0002-8455-980X
Ulrik DalgasExercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-4132-2789
John DeLucaKessler Foundation, West Orange, NJ, USA.
Rachel FarrellQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.ORCID https://orcid.org/0000-0002-2767-3382
Peter FeysREVAL, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.ORCID https://orcid.org/0000-0002-5680-5495
Massimo FilippiNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID https://orcid.org/0000-0002-5485-0479
Jennifer FreemanFaculty of Health, School of Health Professions, University of Plymouth, Devon, UK.
Matilde IngleseDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
Cecilia MezaDepartment of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Maria A RoccaNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID https://orcid.org/0000-0003-2358-4320
Amber SalterDepartment of Neurology, Section on Statistical Planning and Analysis, UT Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0002-1088-110X
Anthony FeinsteinDepartment of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-0132-0909
CogEx Research Team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is heterogeneity of aerobic fitness (VO Objectives: This secondary, exploratory analysis of data examined the heterogeneity of VO Methods: CogEx was a multi-site, multi-arm, randomized, double-blinded, and sham-controlled trial undertaken by 11 sites in six different countries. Participants were randomized into one of four conditions with different combinations of exercise training and cognitive rehabilitation including respective sham conditions. The analysis focuses primarily on VO Results: Waterfall plots for change in VO Conclusion: Our results highlight the heterogeneity of change in VO

Indexed as

Exerciseheterogeneityprogressive MS

Identifiers

PMID39651332
PMCPMC11622331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.