Evidence map›Paper›PMID 39651284›Full record

ArticlebioRxiv : the preprint server for biology2024

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation.

Andrew J MacLean, Lachlan P Deimel, Pengcheng Zhou, Mohamed A ElTanbouly, Julia Merkenschlager, Victor Ramos, Gabriela S Santos, Thomas Hägglöf, Christian T Mayer, Brianna Hernandez and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Andrew J MacLeanLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.ORCID 0009-0008-8378-4141
Lachlan P DeimelLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Pengcheng ZhouLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Mohamed A ElTanboulyLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Julia MerkenschlagerLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Victor RamosLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Gabriela S SantosLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Thomas HägglöfLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Christian T MayerExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Brianna HernandezLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Anna GazumyanLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.
Michel C NussenzweigLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.

Funding

Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6M
Class Switch Recombination in B LymphocytesR37AI037526 · NIAID · ROCKEFELLER UNIVERSITY · PI NUSSENZWEIG, MICHEL C · 2014 to 2023
$5.4M
NIAID NIH HHS R37 AI037526NIAID NIH HHS UM1 AI144462
6 · The paper itself

Abstract

Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, are selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown. Here we report that PC precursors (prePC) expressing high affinity antibodies receive higher levels of T follicular helper (Tfh)-derived help and divide at higher rates than their lower affinity counterparts once they leave the GC. Thus, differential cell division by selected prePCs accounts for how diverse precursors develop into a PC compartment that mediates serological affinity maturation.

Identifiers

PMID39651284
PMCPMC11623657

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.