Evidence map›Paper›PMID 39651257›Full record

ArticlebioRxiv : the preprint server for biology2024

Optimized directed evolution of

Elise D Ficaretta, Tarah J Yared, Subrata Bhattacharjee, Lena A Voss, Rachel L Huang, Abhishek Chatterjee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Elise D FicarettaDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.
Tarah J YaredDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.
Subrata BhattacharjeeDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.
Lena A VossDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.
Rachel L HuangDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.
Abhishek ChatterjeeDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.ORCID 0000-0002-6231-5302

Funding

A genetically encoded toolset to decipher the biology of post-translational modifications in the mammalian proteomeR35GM136437 · NIGMS · BOSTON COLLEGE · PI Abhishek Chatterjee · 2020 to 2026
$4.0M
NIGMS NIH HHS R35 GM136437
6 · The paper itself

Abstract

Site-specific incorporation of noncanonical amino acids (ncAAs) into proteins in eukaryotes has predominantly relied on the pyrrolysyl-tRNA synthetase/tRNA pair. However, access to additional easily engineered pairs is crucial for expanding the structural diversity of the ncAA toolbox in eukaryotes. The

Indexed as

aminoacyl-tRNA synthetasesdirected evolutionGenetic code expansionpost-translational modificationsprotein engineering

Identifiers

PMID39651257
PMCPMC11623586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.